Results 11 to 20 of about 281,346 (214)

Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9

Journal of Lipid Research, 2008
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has gained attention as a key regulator of serum low density lipoprotein cholesterol (LDL-C) levels. This novel protease causes the degradation of hepatic low density lipoprotein receptors. In humans,
Holly E. Careskey, R. Aleks Davis, William E. Alborn, Jason S. Troutt, Guoqing Cao, Robert J. Konrad   +5 more
doaj   +1 more source

LDL-cholesterol to HDL-cholesterol ratio discordance with lipid parameters and carotid intima-media thickness: a cohort study in China

Lipids in Health and Disease, 2020
Background The discordance of the low-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio with alterative lipid parameters may explain the inconsistent association of CIMT with the LDL-C/HDL-C ratio.
Yanmei Lou, Xue Li, Liming Cao, Pei Qin, Jing Shi, Yanyan Zhang, Changyi Wang, Jianping Ma, Li Wang, Xiaolin Peng, Hongen Chen, Shan Xu, Fulan Hu, Yashuang Zhao, Ping Zhao   +14 more
doaj   +1 more source

Peculiarities of Lipid Metabolism in Children with Metabolic Syndrome

Zdorovʹe Rebenka, 2014
Peculiarities of blood lipids in children with metabolic syndrome were studied. We observed 139 children aged 9 to 18 years, who formed two groups: 1st group — 85 children with metabolic syndrome on the background of abdominal obesity, 2nd group — 54 ...
N.M. Gromnatska, S.K. Tkachenko
doaj   +1 more source

Non-high density lipoprotein cholesterol versus low density lipoprotein cholesterol as a discriminating factor for myocardial infarction

BMC Research Notes, 2012
Background Serum total cholesterol (TC) and LDL cholesterol (LDL-C) have been used as major laboratory measures in clinical practice to assess cardiovascular risk in the general population and disease management as well as prognosis in patients. However,
Sigdel Manoj, Yadav Binod, Gyawali Prajwal, Regmi Prashant, Baral Sushil, Regmi Shyam, Jha Bharat   +6 more
doaj   +1 more source

MEDI6012: Recombinant Human Lecithin Cholesterol Acyltransferase, High‐Density Lipoprotein, and Low‐Density Lipoprotein Receptor–Mediated Reverse Cholesterol Transport

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background MEDI6012 is recombinant human lecithin cholesterol acyltransferase, the rate‐limiting enzyme in reverse cholesterol transport. Infusions of lecithin cholesterol acyltransferase have the potential to enhance reverse cholesterol transport and ...
Richard T. George, Liron Abuhatzira, Susan M. Stoughton, Sotirios K. Karathanasis, Dewei She, ChaoYu Jin, Nicholas A. P. S. Buss, Rebecca Bakker‐Arkema, Emily L. Ongstad, Michael Koren, Boaz Hirshberg   +10 more
doaj   +1 more source

Disruption of ldlr causes increased LDL-c and vascular lipid accumulation in a zebrafish model of hypercholesterolemia[S]

Journal of Lipid Research, 2014
Hyperlipidemia and arterial cholesterol accumulation are primary causes of cardiovascular events. Monogenic forms of hyperlipidemia and recent genome-wide association studies indicate that genetics plays an important role.
Elizabeth A. O'Hare, Xiaochun Wang, May E. Montasser, Yen-Pei C. Chang, Braxton D. Mitchell, Norann A. Zaghloul   +5 more
doaj   +1 more source

A retrospective study of lipid profile in SARS-CoV-2 infection

National Journal of Physiology, Pharmacy and Pharmacology, 2023
Background: Coronavirus disease 2019 (COVID-19), a pandemic, infected millions of individuals globally. Several studies have been done on the demographic, clinical, laboratory, and radiological parameters of SARCoV-2 disease.
Syed Imran Ali, Sumera Tasleem, Mohammed Abdul Muqeeth, Ch. B Sai Srinivas, Hajera Rabbani, Farha Tarannum   +5 more
doaj   +1 more source

A U-shaped association between the LDL-cholesterol to HDL-cholesterol ratio and all-cause mortality in elderly hypertensive patients: a prospective cohort study

Lipids in Health and Disease, 2020
Background The low-density lipoprotein cholesterol/high-density lipoprotein- cholesterol (LDL-C/HDL-C) ratio is an excellent predictor of cardiovascular disease (CVD).
Yu Yu, Minghui Li, Xiao Huang, Wei Zhou, Tao Wang, Lingjuan Zhu, Congcong Ding, Yu Tao, Huihui Bao, Xiaoshu Cheng   +9 more
doaj   +1 more source

Assessing the Accuracy of Estimated Lipoprotein(a) Cholesterol and Lipoprotein(a)‐Free Low‐Density Lipoprotein Cholesterol

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Accurate measurement of the cholesterol within lipoprotein(a) (Lp[a]‐C) and its contribution to low‐density lipoprotein cholesterol (LDL‐C) has important implications for risk assessment, diagnosis, and treatment of atherosclerotic ...
Weili Zheng, Michael Chilazi, Jihwan Park, Vasanth Sathiyakumar, Leslie J. Donato, Jeffrey W. Meeusen, Mariana Lazo, Eliseo Guallar, Krishnaji R. Kulkarni, Allan S. Jaffe, Raul D. Santos, Peter P. Toth, Steven R. Jones, Seth S. Martin   +13 more
doaj   +1 more source

Associations between remnant lipoprotein cholesterol and central systolic blood pressure in a Chinese community-based population: a cross-sectional study

Lipids in Health and Disease, 2021
Background The lipid profile is reportedly related to peripheral blood pressure or pulse wave velocity. However, no studies have investigated the associations between lipid parameters, especially remnant lipoprotein cholesterol (RLP-C), and central ...
Kaiyin Li, Fangfang Fan, Bo Zheng, Jia Jia, Bo Liu, Jiahui Liu, Chuyun Chen, Jing Zhou, Yan Zhang, Yong Huo   +9 more
doaj   +1 more source