Results 61 to 70 of about 10,282,391 (249)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Patient doses in ct, dental cone beam ct and projection radiography in Finland, with emphasis on paediatric patients [PDF]

, 2008
Diagnostic radiology represents the largest man-made contribution to population radiation doses in Europe. To be able to keep the diagnostic benefit versus radiation risk ratio as high as possible, it is important to understand the quantitative ...
Kiljunen, Timo
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Image quality and dosimetry of a dual source computed tomography scanner with special emphasis on radiation dose of lung in a chest examination [PDF]

, 2011
The purpose of the current study was to evaluate the Dual Source Computed Tomography scanner in terms of Image quality and dosimetry with special emphasis of radiation dose of lung in a Chest examination.Zielsetzung der Studie war die Evaluation eines ...
Paul, Jijo
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Low Dose Radiation Adaptive Protection to Control Neurodegenerative Diseases

Dose-Response, 2014
Concerns have been expressed recently regarding the observed increased DNA damage from activities such as thinking and exercise. Such concerns have arisen from an incomplete accounting of the full effects of the increased oxidative damage.
Mohan Doss
doaj   +1 more source

A Multidisciplinary Perspective on the Linear No-Threshold (LNT) Model: Summary of the 2025 Korean Association for Radiation Protection Winter Workshop [PDF]

Journal of Radiation Protection and Research
The linear no-threshold (LNT) model has long served as a foundational principle in radiation protection. In recent years, advances in radiation health science, along with legal and social debate over the model’s application in administrative and judicial
Songwon Seo, Min Baek
doaj   +1 more source

Radiation dose estimates for radiopharmaceuticals

, 1996
Tables of radiation dose estimates based on the Cristy-Eckerman adult male phantom are provided for a number of radiopharmaceuticals commonly used in nuclear medicine.
Stubbs, J. B., Toohey, R. E., Stabin, M. G.   +2 more
core   +1 more source

Multidisciplinary European Low Dose Initiative (MELODI): strategic research agenda for low dose radiation risk research [PDF]

, 2017
MELODI (Multidisciplinary European Low Dose Initiative) is a European radiation protection research platform with focus on research on health risks after exposure to low-dose ionising radiation.
Prise, K M; id_orcid, Auvinen, A, E. Cardis, Auvinen, A., Madas, B.G., J. R. Jourdain, Kreuzer, M, R. Quintens, S. Pazzaglia, Kreutzer, M, Ottolenghi, A, S. Bouffler, Jourdain, J.R., Kreuzer, M., Quintens, R., Sabatier, L., Cardis, E, Prise, KM, Bouffler, S, Harms-Ringdahl, Mats,, Madas, BG, M. Harms-Ringdahl, Harms-Ringdahl, M., Ottolenghi, A., Pazzaglia, S., Prise, K. M., Prise, K.M., Madas, B. G., Cardis, E., Jourdain, J. R., K. M. Prise, L. Sabatier, Sabatier, L, Jourdain, J R, Pazzaglia, S, Durante, M., Durante, M, M. Durante, Jourdain, JR, Quintens, R, B. G. Madas, Bouffler, S., M. Kreuzer, A. Ottolenghi, Madas, B G, Harms-Ringdahl, M, A. Auvinen   +46 more
core   +1 more source