Results 21 to 30 of about 126,936 (262)

Clinical Intervention Using Focused Ultrasound (FUS) Stimulation of the Brain in Diverse Neurological Disorders

Frontiers in Neurology, 2022
Various surgical techniques and pharmaceutical treatments have been developed to improve the current technologies of treating brain diseases. Focused ultrasound (FUS) is a new brain stimulation modality that can exert a therapeutic effect on diseased ...
Hongchae Baek, Hongchae Baek, Daniel Lockwood, Emily Jo Mason, Emmanuel Obusez, Matthew Poturalski, Richard Rammo, Sean J. Nagel, Stephen E. Jones   +8 more
doaj   +1 more source

Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy

Frontiers in Neuroscience, 2022
Epilepsy affects about 1% of the population. Approximately one third of patients with epilepsy are drug-resistant (DRE). Resective surgery is an effective treatment for DRE, yet invasive, and not all DRE patients are suitable resective surgery candidates.
Emma Lescrauwaet, Kristl Vonck, Mathieu Sprengers, Mathieu Sprengers, Robrecht Raedt, Debby Klooster, Debby Klooster, Evelien Carrette, Paul Boon, Paul Boon   +9 more
doaj   +1 more source

Low-Intensity Focused Ultrasound Modulates Monkey Visuomotor Behavior [PDF]

Current Biology, 2013
In vivo feasibility of using low-intensity focused ultrasound (FUS) to transiently modulate the function of regional brain tissue has been recently tested in anesthetized lagomorphs [1] and rodents [2-4]. Hypothetically, ultrasonic stimulation of the brain possesses several advantages [5]: it does not necessitate surgery or genetic alteration but could
Deffieux, Thomas, Younan, Youliana, Wattiez, Nicolas, Tanter, Mickael, Pouget, Pierre, Aubry, Jean-François   +5 more
openaire   +2 more sources

Therapeutic Ultrasound-Enhanced Immune Checkpoint Inhibitor Therapy

Frontiers in Physics, 2021
Immune checkpoint inhibitors (ICIs) are designed to reinvigorate antitumor immune responses by interrupting inhibitory signaling pathways and promote the immune-mediated elimination of malignant cells.
Jinyun Yuan, Dezhuang Ye, Si Chen, Hong Chen, Hong Chen   +4 more
doaj   +1 more source

Low Intensity Focused Ultrasound for Epilepsy- A New Approach to Neuromodulation. [PDF]

Epilepsy Curr, 2022
Patients with drug-resistant epilepsy (DRE) who are not surgical candidates have unacceptably few treatment options. Benefits of implanted electrostimulatory devices are still largely palliative, and many patients are not eligible to receive them. A new form of neuromodulation, low intensity focused ultrasound (LIFUS), is rapidly emerging, and has ...
Bubrick EJ, McDannold NJ, White PJ.
europepmc   +3 more sources

Measurement of low-intensity highly focused ultrasound [PDF]

The Journal of the Acoustical Society of America, 1986
The requirements for precise determination of acoustic output for different types of medical diagnostic equipment have made it important to develop methods of measuring ultrasonic field parameters at high megahertz range of frequencies. More specifically, of particular interest here is the measurement of pulsed beams of small focal diameters (of the ...
George H. Myers, Peter A. Lewin, Mark E. Schafer   +2 more
openaire   +1 more source

Preconditioning of mesenchymal stromal cells with low-intensity ultrasound: influence on chondrogenesis and directed SOX9 signaling pathways [PDF]

, 2020
Background: Continuous low-intensity ultrasound (cLIUS) facilitates the chondrogenic differentiation of human mesenchymal stromal cells (MSCs) in the absence of exogenously added transforming growth factor-beta (TGFβ) by upregulating the expression of ...
A Argentaro, A Augello, A Katsumi, A Woods, A Woods, AD Miller, AH Huang, B Yang, BH Choi, C Huang, C Matta, CA Simmons, CB Little, CJ O’Conor, CY Huang, D Schumann, DR Haudenschild, EM Darling, F Dell'Accio, G Coricor, H Sim, H-C Hsu, HJ Kwon, HJ Lee, HJ Lee, J Li, J Puetzer, JC Sng, JD Kisiday, JH Cui, JH Cui, JW Choi, K Ebisawa, K Pelttari, L Bian, Li Ling, LJ Ng, M Shakibaei, M Tsuda, MA Corrigan, MB Mueller, N Fahy, N Thelin, NP Whitney, P Müller, R Ogawa, RL Mauck, RM Delaine-Smith, RS Tigli, S Murakami, S Noriega, S Noriega, S Yamaguchi, SD Cook, SD Cook, T Furumatsu, T Guo, T Ito, T Juhasz, T Nishida, T Sanjukta Guha, TM Louw, V Lefebvre, V Lefebvre, W Huang, W Huang, Z Li, ZJ Zhang   +67 more
core   +2 more sources

The role of ultrasound-driven microbubble dynamics in drug delivery : from microbubble fundamentals to clinical translation [PDF]

, 2019
In the last couple of decades, ultrasound-driven microbubbles have proven excellent candidates for local drug delivery applications. Besides being useful drug carriers, microbubbles have demonstrated the ability to enhance cell and tissue permeability ...
De Smedt, Stefaan, Deprez, Joke, Lajoinie, Guillaume, Lentacker, Ine, Roovers, Silke, Segers, Tim, Versluis, Michel   +6 more
core   +9 more sources

A review of low-intensity focused ultrasound for neuromodulation [PDF]

Biomedical Engineering Letters, 2017
The ability of ultrasound to be focused into a small region of interest through the intact skull within the brain has led researchers to investigate its potential therapeutic uses for functional neurosurgery and tumor ablation. Studies have used high-intensity focused ultrasound to ablate tissue in localised brain regions for movement disorders and ...
Hongchae, Baek, Ki Joo, Pahk, Hyungmin, Kim   +2 more
openaire   +2 more sources

Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound Treatment at 1.5 T: A Retrospective Study on Treatment- and Patient-Related Parameters Obtained From 52 Procedures [PDF]

, 2020
Objective: To present a retrospective analysis of patient- and sonication-related parameters of a group of patients treated with a transcranial magnetic resonance imaging (MRI)-guided focused ultrasound (tcMRgFUS) system integrated with a 1.5-T MRI unit.
Bartolotta TV, Borgese RF, Cannella R, Catalano C, Collura G, D’Amelio M, D’Angelo C, Gagliardo C, Iacopino G, Lagalla R, Marrale M, Midiri M, Napoli A   +12 more
core   +1 more source