Results 81 to 90 of about 215,416 (267)

Assessing Neuronal Loss after Repeated Low-Level Blast Injury

, 2023
Explosive weaponry such as IEDs accounts for over 50% of traumatic brain injury (TBI) in 21st-century warfare. The sudden detonation of these explosives causes the release of a shock wave that can cause TBI.
openaire   +1 more source

Widespread distribution of resistance to triazole fungicides in Brazilian populations of the wheat blast pathogen

, 2020
Fungicides have not been effective in controlling the wheat blast disease in Brazil. An earlier analysis of 179 isolates of Pyricularia oryzae Triticum lineage (PoTl) sampled from wheat fields across six populations in central‐southern Brazil during 2012
Dorigan, A. F., Vicentini, S. N. C., Hawkins, N. J., Fraaije, B. A., Kelly, D. E., Ceresini, P. C., Kelly, S. L., Moreira, S. I., McDonald, B. A., Poloni, N. M., Carvalho, G., Maciel, J. L. N.   +11 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Thoracic Mechanism of Mild Traumatic Brain Injury Due to Blast Pressure Waves

, 2008
The mechanisms by which blast pressure waves cause mild to moderate traumatic brain injury (mTBI) are an open question. Possibilities include acceleration of the head, direct passage of the blast wave via the cranium, and propagation of the blast wave to
Michael Courtney, Amy Courtney
core  

Data_Sheet_1_Repeated Low-Level Blast Overpressure Leads to Endovascular Disruption and Alterations in TDP-43 and Piezo2 in a Rat Model of Blast TBI.docx

, 2019
Recent evidence linking repeated low-level blast overpressure exposure in operational and training environments with neurocognitive decline, neuroinflammation, and neurodegenerative processes has prompted concern over the cumulative deleterious effects ...
Joseph B. Long (7055063), Andrew Batuure (7055051), Jonathan Statz (7055054), Lanier Heyburn (7055039), Rania Abutarboush (7055042), Stephen T. Ahlers (7055060), Venkata Siva Sai Sujith Sajja (7055066), Rodrigo Urioste (7055048), Samantha Goodrich (7055045), Donna Wilder (7055057)   +9 more
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

The BLAST Scientific Program

, 2007
Introduction The primary motivation for the BLAST detector is to carry out a comprehensive program of measurements of the spin dependent electromagnetic response of the few body systems.
R. Alarcon, Blast Collaboration
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Associations between concussion and more severe TBIs, mild cognitive impairment, and early-onset dementia among military retirees over 40 years

Frontiers in Neurology
Background and objectivesAs the population of U.S. service members (SMs) who have sustained concussions and more severe traumatic brain injuries (TBIs) during military service ages, understanding the long-term outcomes associated with such injuries will ...
Jennifer N. Belding, Jennifer N. Belding, James Bonkowski, James Bonkowski, Robyn Englert, Robyn Englert, Ansley Grimes Stanfill, Jack W. Tsao   +7 more
doaj   +1 more source