Results 81 to 90 of about 477,305 (254)

Routine use of microarray-based gene expression profiling to identify patients with low cytogenetic risk acute myeloid leukemia: accurate results can be obtained even with suboptimal samples

BMC Medical Genomics, 2012
Background Gene expression profiling has shown its ability to identify with high accuracy low cytogenetic risk acute myeloid leukemia such as acute promyelocytic leukemia and leukemias with t(8;21) or inv(16).
de la Blétière Diane Raingeard, Blanchet Odile, Cornillet-Lefèbvre Pascale, Coutolleau Anne, Baranger Laurence, Geneviève Franck, Luquet Isabelle, Hunault-Berger Mathilde, Beucher Annaelle, Schmidt-Tanguy Aline, Zandecki Marc, Delneste Yves, Ifrah Norbert, Guardiola Philippe   +13 more
doaj   +1 more source

A Comparison of Ultraviolet, Optical, and X-Ray Imagery of Selected Fields in the Cygnus Loop

, 2000
During the Astro-1 and Astro-2 Space Shuttle missions in 1990 and 1995, far ultraviolet (FUV) images of five 40' diameter fields around the rim of the Cygnus Loop supernova remnant were observed with the Ultraviolet Imaging Telescope (UIT).
Bedogni R., Charles W. Danforth, Innes D. E., N. A. Levenson, Nussbaumer H., Robert H. Cornett, Theodore P. Stecher, William P. Blair   +7 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Outbreak of Rice Panicle Blast in Southern Provinces of Korea in 2014

Research in Plant Disease, 2019
Rice panicle blast occurred severely in southern provinces of Korea in 2014. The proportion of panicle blast incidence area to cultivated area of rice were 11.0% and 14.6% in Jeollanam-do and Gyeongsangnam-do, respectively. To identify the causal factors
Wee Soo Kang, Myung-Chul Seo, Seong Jun Hong, Kyong Jae Lee, Yong Hwan Lee   +4 more
doaj   +1 more source

Finite element simulation of plates under non-uniform blast loads using a point-load method: Blast wave clearing [PDF]

, 2015
There are two primary challenges associated with assessing the adequacy of a protective structure to resist explosive events: firstly the spatial variation of load acting on a target must be predicted to a sufficient level of accuracy; secondly, the ...
Clarke, S.D., Fay, S.D., Reay, J.J., Rigby, S.E., Tyas, A., Warren, J.A.   +5 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Synchrotron signature of a relativistic blast wave with decaying microturbulence

, 2012
Microphysics of weakly magnetized relativistic collisionless shock waves, corroborated by recent high performance numerical simulations, indicate the presence of a microturbulent layer of large magnetic field strength behind the shock front, which must ...
Achterberg, Ackermann, Barniol-Duran, Barniol-Duran, Barniol-Duran, Barniol-Duran, Begelman, Bykov, Caprio, Chang, Corsi, de Pasquale, Derishev, Fleishman, Gallant, Gao, Ghirlanda, Ghisellini, Golenetskii, Granot, Granot, Gruzinov, Guiriec, He, Hoversten, Katz, Keshet, Kirk, Lemoine, Lemoine, Lemoine, Lemoine, Lemoine, Lemoine, Lemoine, Leroy, Li, Li, Longo, Lyubarsky, M. Lemoine, Mao, Martins, Medvedev, Medvedev, Medvedev, Mészáros, Nicuesa, Niemiec, Nousek, Ohmori, O’Brien, Panaitescu, Panaitescu, Pelletier, Piran, Piran, Plotnikov, Rabinak, Razzaque, Reville, Rossi, Rybicki, Sagi, Sari, Sari, Sironi, Sironi, Spitkovsky, Ukwatta, Wang, Wijers   +71 more
core   +1 more source

Optical shaping of gas targets for laser plasma ion sources [PDF]

, 2016
We report on the experimental demonstration of a technique to generate steep density gradients in gas-jet targets of interest to laser–plasma ion acceleration. By using an intentional low-energy prepulse, we generated a hydrodynamic blast wave in the gas
Cook, N, Dover, N, Ettlinger, O, Maharjan, C, Najmudin, Z, Pogorelsky, I, Polyanskiy, M, Shkolnikov, P, Tresca, O   +8 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source