Results 61 to 70 of about 198,375 (333)

Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening

Advanced Healthcare Materials, EarlyView.
Models of the human skin must combine the relevant biological contents and suitable biomaterials with the correct spatial organization. Performing compound screening on such in vitro models also requires fast and reproducible production methods of the models.
Elisa Lenzi, Nadia Vertti‐Quintero, Julien Husson, Anne‐Laure Bulteau, Carine Nizard, Karl Pays, Sébastien Sart, Charles N. Baroud   +7 more
wiley   +1 more source

The anti-factor Xa range for low molecular weight heparin thromboprophylaxis

Hematology Reports, 2015
Low molecular weight heparins (LMWHs) are now the mainstay option in the prevention and treatment of venous thromboembolism. In some patients receiving therapeutic doses of LMWH, activity can be measured by quantifying the presence of Anti-factor Xa ...
Matthew Y. Wei, Salena M. Ward
doaj   +1 more source

Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients

EBioMedicine, 2020
Coronavirus disease-2019 (COVID-19) is associated with severe inflammation in mainly the lung, and kidney. Reports suggest a beneficial effect of the use of heparin/low molecular weight heparin (LMWH) on mortality in COVID-19.
Baranca Buijsers, Cansu Yanginlar, Marissa L. Maciej-Hulme, Quirijn de Mast, Johan van der Vlag   +4 more
doaj   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Comparisons of anticoagulatory and therapeutic effects of low-molecular-weight heparin sodium versus sodium citrate in patients with severe acute kidney injury on continuous renal replacement therapy

Linchuang shenzangbing zazhi, 2021
Objective To explore the effects of sodium citrate anticoagulation on inflammatory state in patients with severe acute renal injury（AKI）on continuous renal replacement therapy（CRRT）.Methods From January 2018 to December 2019,50 AKI patients on CRRT in ...
Munire Abuliz, Zhang Jing-jing, Munire Erken, Li Su-hua, Wang Shun   +4 more
doaj  

Multifunctional and biologically active matrices from multicomponent polymeric solutions [PDF]

, 2012
A functionalized electrospun matrix for the controlled-release of biologically active agents, such as growth factors, is presented. The functionalized matrix comprises a matrix polymer, a compatibilizing polymer and a biomolecule or other small ...
Casper, Cheryl, Kiick, Kristi L., Rabolt, John, Yamaguchi, Nori   +3 more
core   +1 more source

Multi-component hybrid hydrogels – understanding the extent of orthogonal assembly and its impact on controlled release [PDF]

, 2017
This paper reports self-assembled multi-component hybrid hydrogels including a range of nanoscale systems and characterizes the extent to which each component maintains its own unique functionality, demonstrating that multi-functionality can be achieved ...
Abidine, Abul-Haija, Adams, Ahola, Albanyan, Amabilino, Babu, Banerjee, Beamish, Bimalendu, Boekhoven, Boekhoven, Bonina, Brizard, Bromfield, Bromfield, Bromfield, Bromfield, Bromfield, Buerkle, Calamai, Chakraborty, Chakraborty, Chau, Chen, Colquhoun, Cornwell, Cornwell, Cornwell, Corwnell, Das, Das, Draper, Draper, Du, Edelman, Escuder, Fan, Fechner, Fernández-Muiños, Fleming, Gutowska, Gutowska, Hanabusa, Heeres, Himmelein, Hirst, Hirst, Hirst, Hoare, Hou, Hussein, Iannuzzi, Kim, Laupheimer, Lee, Li, Liechty, Liu, Liu, Loira-Pastoriza, McLennan, Metanovic, Middeldorp, Moffat, Moffat, Morris, Nebot, Okesola, Onogi, Onogi, Pont, Rabenstein, Radivojsa, Raeburn, Raeburn, Rahfoth, Rajangam, Recha-Sancho, Rodrigo, Roveri, Sakiyama-Elbert, Sakiyama-Elbert, Sakiyama-Elbert, Sangeetha, Serwer, Singh, Skilling, Stubenrauch, Vieira, Wang, Webber, Wlodarczyk-Biegun, Yu   +93 more
core   +1 more source

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

pH-Sensitive Chitosan–Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells [PDF]

, 2019
Chitosan has been extensively studied as a genetic drug delivery platform. However, its efficiency is limited by the strength of DNA and RNA binding.
Korzhikov-Vlakh, Viktor, Pilipenko, Iuliia, Rühl, Eckart, Schäfer-Korting, Monika, Sharoyko, Vladimir, Tennikova, Tatiana, Zhang, Nan, Zoschke, Christian   +7 more
core   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source