Results 81 to 90 of about 12,776,407 (326)

Differentiation of parenteral anticoagulants in the prevention and treatment of venous thromboembolism

Thrombosis Journal, 2011
Background The prevention of venous thromboembolism has been identified as a leading priority in hospital safety. Recommended parenteral anticoagulant agents with different indications for the prevention and treatment of venous thromboembolism include ...
Adiguzel Cafer, Fareed Jawed, Thethi Indermohan   +2 more
doaj   +1 more source

Preparation of low molecular weight heparin using an ultrasound-assisted Fenton-system

Ultrasonics sonochemistry, 2018
Heparin, a high-molecular weight acidic polysaccharide, has raised much interest in the field of biomedical research due to its multiple bio-functions.
Zi-Jian Zhi, Jun-Hui Li, Jian-Le Chen, Shan Li, Huan Cheng, Dong-Hong Liu, Xing-Qian Ye, R. Linhardt, Shi-Guo Chen   +8 more
semanticscholar   +1 more source

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

Advanced Science, EarlyView.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic   +21 more
wiley   +1 more source

Low molecular weight heparin-induced thrombocytopenia management during hemodialysis and cardiac surgery: a case report and literature review

JA Clinical Reports
Background Heparin-induced thrombocytopenia (HIT) is a serious complication of heparin therapy, including low molecular weight heparins (LMWHs) like dalteparin.
Shuto Takada, Shogo Suzuki, Takahiro Tamura   +2 more
doaj   +1 more source

Risk Factors of Bleeding after Subcutaneous Injection of Low-molecular-weightHeparin in Elderly Patients with Unstable Angina Pectoris and Asthenia

Guoji laonian yixue zazhi
Objective To analyze the risk factors of bleeding after subcutaneous injection of low-molecular-weight heparin in elderly patients with unstable angina pectoris and weakness.
Qi Wu, Meili Ji, Rong Zhang, Danlei Wang, Peipei Xia   +4 more
doaj   +1 more source

Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells

Brazilian Journal of Medical and Biological Research, 2001
The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed.
H.B. Nader, M.A.S. Pinhal, E.C. Baú, R.A.B. Castro, G.F. Medeiros, S.F. Chavante, E.L. Leite, E.S. Trindade, S.K. Shinjo, H.A.O. Rocha, I.L.S. Tersariol, A. Mendes, C.P. Dietrich   +12 more
doaj   +1 more source

In vitro synthesis of heparosan using recombinant Pasteurella multocida heparosan synthase PmHS2 [PDF]

, 2009
In vertebrates and bacteria, heparosan the precursor of heparin is synthesized by glycosyltransferases via the stepwise addition of UDP-N-acetylglucosamine and UDP-glucuronic acid.
Kooy, F.K., Eggink, G., Springer, J., Chavaroche, A.A.E., Anaïs A. E. Chavaroche, Boeriu, C.G., Floor Kooy, Gerrit Eggink, Jan Springer, Carmen Boeriu   +9 more
core   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Rational Design of Anticoagulant Drugs Using Oligosaccharide Chemistry

CHIMIA, 2011
For a long time, heparin and low molecular weight heparins have been the drugs of choice for the management of thrombosis. Discovery of the antithrombin binding domain in heparin, a critical element in the anticoagulant activity of this ...
Ahmed El Hadri, Maurice Petitou
doaj   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source