Results 61 to 70 of about 10,778,698 (292)

Thermodynamic Analysis of Effects of the Inlet Air Cooling on Cycle Performance in Combined Brayton-Diesel Cycle

open access: yesHittite Journal of Science and Engineering, 2020
In the present study, the effects of inlet air cooling on compound cycle performance in a diesel gas turbine engine system where waste heat is used in the composite power system in the sustainable energy system were investigated thermodynamically.
Betul Sarac, Teoman Ayhan
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Ni Interlayer to Improve Low-Pressure Diffusion Bonding of 316L SS Press Fit Tube-to-Tubesheet Joints for Coiled Tube Gas Heaters [PDF]

open access: yesJournal of Nuclear Engineering and Radiation Science, 2017
This study suggests a new approach to diffusion bonding (DB) 316L stainless steel: a low-pressure procedure that includes a nickel interlayer. In this approach, relatively lower pressure is applied to the sample before the DB process, in contrast to the usual approach in which higher pressure is applied during the DB process.
Rony Reuven   +7 more
openaire   +1 more source

Electrical heater for very-low pressure helium gas [PDF]

open access: yes, 1996
Testing superconducting magnets for the Large Hadron Collider (LHC) in superfluid helium requires large-capacity refrigeration at 1.8K. At CERN, this is provided by a combination of a cold compressor and a set of warm vacuum pumps capable of handling up ...
Sergo, V, Vuillierme, B, Benda, V
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

How Does Turbo Heater 3 Work?

open access: yes, 2021
People are uncommon inventive creatures; they can recognize issues and proffer durable answers for them. For example, it's colder time of year and you're cold, so you wrap the cover over you.
Turbo Heater 3
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

HYDRODYNAMIC AND HEAT TRANSFER STUDIES IN RISER SYSTEM FOR WASTE HEAT RECOVERY USING LIMESTONE [PDF]

open access: yesJournal of Engineering Science and Technology, 2018
Suspension pre-heater (SP) system has been a unique development in the field of cement manufacture. A modern dry process cement plant vitally constitutes, the suspension pre-heater and the pre-calcinator, which together account for a drastic reduction in
A. K. POPURI, P. GARIMELLA
doaj  

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