Results 71 to 80 of about 208,229 (308)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Modelling Low Velocity Impact on Structural Composites

IOP Conference Series: Materials Science and Engineering, 2020
Abstract Insertion of composite materials into next generation vehicles requires an understanding of their response over the range of relevant loading conditions encountered in the field. This paper focuses on modelling the low velocity, high energy impact on structural composite materials.
M Yeager, S E Boyd, J M Staniszewski, B A Patterson, D B Knorr, T A Bogetti   +5 more
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Evaluation of Force-Time Changes During Impact of Hybrid Laminates Made of Titanium and Fibrous Composite

Archives of Metallurgy and Materials, 2016
Fibre metal laminates (FML) are the modern hybrid materials with potential wide range of applications in aerospace technology due to their excellent mechanical properties (particularly fatigue strength, resistance to impacts) and also excellent corrosion
Jakubczak P., Surowska B., Bieniaś J.
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Chicxulub central crater structure: Initial results from physical property measurements and combined velocity and gravity modeling

, 2004
The Chicxulub crater in Mexico is a nearly pristine example of a large impact crater. Its slow burial has left the central impact basin intact, within which there is an apparently uneroded topographic peak ring.
Vermeesch, Peggy M., Morgan, J. V., Vermeesch, P. M., Morgan, Joanna V.   +3 more
core   +1 more source

Low Velocity Impact Monitoring of Composite Tubes Based on FBG Sensors

Sensors
Carbon fiber reinforced composites (CFRP) are susceptible to hidden damage from low velocity external impacts during their service life. To ensure the proper monitoring of the state of the composites, it is crucial to predict the location of an impact ...
Shengsheng Huan, Linjiao Lu, Tao Shen, Jianke Du   +3 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Localised low velocity impact performance of short glass fibre reinforced polyamide 66 oil pans [PDF]

, 2012
This thesis focuses on the mechanical properties of short glass fibre reinforced polyamide 66 material used in automotive composite structures, and its impact resistance under localised low velocity impact.
Mouti, Zakaria
core