Results 61 to 70 of about 208,229 (308)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Colloidal transport of heavy metals in low‐advective‐velocity environmental systems: Reactive transport model on biogeochemical and hydrodynamic impacts

Vadose Zone Journal, 2023
In this study, the impact of colloid facilitated transport of heavy metals on the overall biogeochemical processes is demonstrated in example Lake Coeurd'Alene sediments. Release and transport of heavy metals (Pb and Zn) on initially sorbed colloidal Fe (
S. Sevinç Şengör, Kahraman Ünlü
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Mechanical protection for composite structures submitted to low energy impact [PDF]

, 2010
Composite materials are widely used in aeronautical structures. These materials can be submitted to low energy impacts like tool drop, routine operations… Such impacts can generate damages in the material that significantly reduce the structure strength.
Bouvet, Christophe, Valembois, Guy, Rivallant, Samuel, Fascio, Valia, Rahmé, Pierre   +4 more
core  

A review of recent advancements in the impact response of fiber metal laminates

Heliyon
Fiber metal laminates (FMLs) have garnered significant attention due to their exceptional impact resistance, making them attractive for various structural applications. This review presents recent advancements in understanding the impact behavior of FMLs
Vijayan Muniyan, Vishnu Vijay Kumar, Indran Suyambulingam, Suganya Priyadharshini, Divya Divakaran, Sanjay Mavinkere Rangappa, Suchart Siengchin   +6 more
doaj   +1 more source

Significance low oscillating magnetic field and Hall current in the nano-ferrofluid flow past a rotating stretchable disk

Scientific Reports, 2021
The present investigation involves the Hall current effects past a low oscillating stretchable rotating disk with Joule heating and the viscous dissipation impacts on a Ferro-nanofluid flow.
Muhammad Ramzan, Saima Riasat, Yan Zhang, Kottakkaran Sooppy Nisar, Irfan Anjum Badruddin, N. Ameer Ahammad, Hassan Ali S. Ghazwani   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Injury Evaluation of Human-Robot Impacts

, 2008
Currently, large efforts are unertaken to bring robotic applications to domestic environments. Especially physical human-robot cooperation is a major concern and various design and control methodologies were developed on the way to achieve this task.
Hirzinger, Gerd, Albu-Schäffer, Alin Olimpiu, Michael Strohmayr, Haddadin, Sami, Alin Albu-Schaffer, Frommberger, Mirko, Gerd Hirzinger, Strohmayr, Michael, Sami Haddadin, Mirko Frommberger   +9 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Low-velocity impact behaviour of fibreglass–aluminium laminates

Composites Part A: Applied Science and Manufacturing, 2004
Abstract Low-velocity impact tests were performed on fibreglass–aluminium composites made of 2024 T3 sheets and S2-glass/epoxy prepreg layers, using an instrumented falling weight machine. For comparison purposes, similar tests were carried out on monolithic 2024 T3 sheets of equivalent thickness. In the tests, the impact speed, mass, and energy were
CAPRINO, GIANCARLO, SPATARO G, DEL LUONGO S.   +2 more
openaire   +2 more sources