Results 81 to 90 of about 55,861 (283)

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, EarlyView.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

Validation of Portuguese version of the low anterior resection syndrome score

Journal of Coloproctology, 2019
Objective: The authors aim to perform a thorough translation with cultural adaptation of the patient reported outcome tool, Low Anterior Resection Syndrome (LARS) Score, to the Portuguese language (LARS-PT) in the Portuguese population with rectal cancer,
Nuno José Rama, Pedro Lopes Ferreira, João Pimentel, Therese Juul   +3 more
doaj   +1 more source

Assessing the role of anastomotic level in low anterior resection (LAR) surgery among rectal cancer patients in the development of LAR syndrome: a systematic review study

BMC Surgery, 2023
Background The etiology of LARS has not been elaborated on clearly. Studies have reported neoadjuvant therapy, low-lying rectal cancers, adjuvant therapy and anastomotic leakage as risk factors for the development of LARS. Anastomotic level has also been
Mohammad Reza Hashempour, Muhammadhosein Moradi, Reza Ghasemian oroomi, Siamak Daneshvar, Alipasha Meysamie, Mohammadreza Nikshoar, Fakhrosadat Anaraki   +6 more
doaj   +1 more source

Clinically indicated electrical stimulation strategies to treat patients with medically refractory epilepsy. [PDF]

, 2018
Focal epilepsies represent approximately half of all diagnoses, and more than one-third of these patients are refractory to pharmacologic treatment.
Gurkoff, Gene, Izadi, Ali, Keselman, Inna, Ondek, Katelynn, Schedlbauer, Amber, Shahlaie, Kiarash   +5 more
core   +1 more source

Impact of Low Preoperative Prognostic Immune Nutritional Index on Survival and Postoperative Infectious Complications in Patients With Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim The prognostic immune nutritional index (PINI) is increasingly recognized for its potential clinical utility. However, multifaceted evaluations of its ability to predict oncological outcomes in colorectal cancer (CRC) and its association with postoperative infectious complications remain limited.
Shinji Yamashita, Yoshinaga Okugawa, Hiroki Imaoka, Tadanobu Shimura, Takahito Kitajima, Mikio Kawamura, Yoshiki Okita, Masaki Ohi, Minako Kobayashi, Yuji Toiyama   +9 more
wiley   +1 more source

Structural imaging biomarkers of sudden unexpected death in epilepsy. [PDF]

, 2015
Sudden unexpected death in epilepsy is a major cause of premature death in people with epilepsy. We aimed to assess whether structural changes potentially attributable to sudden death pathogenesis were present on magnetic resonance imaging in people who ...
Balestrini, Simona, Diehl, Beate, Duncan, John S, Harper, Ronald M, Koepp, Matthias, Lhatoo, Samden, Micallef, Caroline, Sander, Josemir W, Scott, Catherine, Sisodiya, Sanjay M, Thom, Maria, Vos, Sjoerd B, Wandschneider, Britta   +12 more
core   +3 more sources

Essential Updates 2024/2025: History, Pathogenesis, Definition, Prevention, and Management of Small‐for‐Size Syndrome in Living‐Donor Liver Transplantation

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Although living‐donor liver transplantation (LDLT) has become the standard treatment for end‐stage liver disease, one of its major challenges is small‐for‐size syndrome (SFSS). SFSS is characterized by severe icterus and intractable ascites, although the severity of the condition can vary.
Toru Ikegami, Masashi Tsunematsu, Shinji Onda, Kenei Furukawa, Koichiro Haruki, Michinori Matsumoto, Yoshihiro Shirai   +6 more
wiley   +1 more source

The status of low anterior resection syndrome: data from a single-center in China

BMC Surgery, 2023
Aim The incidence and risk factors of low anterior resection syndrome (LARS) largely variate in different studies. In addition, there is lack of study on how patients evaluate the therapeutic effect of LARS. This single-center retrospective study aims to
Jing Su, Qianhui Liu, Dagui Zhou, Xiaofeng Yang, Guiru Jia, Lijun Huang, Xiao Tang, Jiafeng Fang   +7 more
doaj   +1 more source

Combination of Ethoxybenzyl‐Diethylenetriamine Pentaacetic Acid‐Enhanced Magnetic Resonance Imaging and a Serum Biomarker Is Useful in the Diagnosis of Hepatic Sinusoidal Disorder After Chemotherapy Treatment

Annals of Gastroenterological Surgery, EarlyView.
ROC analyses of APRI score, EOB‐MRI, and a combination of EOB‐MRI and APRI score for blue liver. ABSTRACT Aim Sinusoidal obstruction syndrome (SOS), also known as “blue liver (BL),” is a common hepatic injury following oxaliplatin‐based chemotherapy in patients with colorectal liver metastases (CRLM).
Tomonari Shimagaki, Keishi Sugimachi, Takahiro Tomino, Takeshi Kurihara, Emi Onishi, Yutaro Shimomura, Kenji Shinozaki, Masaru Morita   +7 more
wiley   +1 more source

Can the POLARS tool accurately predict low anterior resection syndrome in rectal cancer patients undergoing laparoscopic resection?

Archives of Medical Science, 2019
Introduction Radical rectal cancer resection can lead to a long-term bowel function impairment known as low anterior resection syndrome (LARS). It remains unclear how to determine which patients are at a higher risk of developing LARS post-surgery.
Paweł Bogacki, Jan Krzak, Tomasz Gach, Wojciech Szwed, Mirosław Szura   +4 more
doaj   +1 more source