Results 61 to 70 of about 1,096,019 (304)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone [PDF]

, 2019
Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralization), and continues slowly (secondary mineralization) until bone is remodeled. The interconnected osteocyte network within the
Vrahnas, Christina, Blank, Martha, Dite, Toby A, Tatarczuch, Liliana, Ansari, Niloufar, Crimeen-Irwin, Blessing, Nguyen, Huynh, Forwood, Mark R, Hu, Yifang, Ikegame, Mika, Bambery, Keith R, Petibois, Cyril, Mackie, Eleanor J, Tobin, Mark J, Smyth, Gordon K, Oakhill, Jonathan S, Martin, T John, Sims, Natalie A   +17 more
core   +1 more source

Risk factors of low peak bone mass in Indonesian women

Jurnal Gizi Klinik Indonesia, 2014
Background: Osteoporosis occurred in 64% of Indonesian women aged 60-64 years. The risk of osteoporosis can be reduced by achieving optimal peak bone mass in ages 25-32 years. However, 33.4% women had low peak bone mass (LPBM).
Ray Sugianto, Johana Titus, Minarma Siagian   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Change in bone mineral density in post menopausal women with rheumatoid arthritis [PDF]

, 2013
Introduction: Low bone mass is a serious complication of post menopausal women with rheumatoid arthritis. We determined the Change in Bone Mineral Density in postmenopausal women with rheumatoid arthritis.
Aghaei, M., Aili, A., Jamshir, M., Khani, S.H., Mohebi, E.G., Pour, N.B., Sedighi, S., Shirashiani, M., Shojaa, M., Zayeni, H.   +9 more
core   +1 more source

Association between low bone mass and calcium and caffeine intake among perimenopausal women in Southern Brazil: cross-sectional study

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Osteoporosis is a skeletal abnormality characterized by reduction and alteration of bone microarchitecture that results in increased fragility and greater predisposition to fractures.
Daniele Lazzarotto Harter, Fernanda Michielin Busnello, Raquel Papandreus Dibi, Airton Tetelbom Stein, Sergio Kakuta Kato, Carla Maria De Martini Vanin   +5 more
doaj   +1 more source

Osteoanabolics

Indian Journal of Endocrinology and Metabolism, 2012
Osteoporosis is characterized by reduced bone mass, impaired bone quality, and a propensity to fracture. An "osteoanabolic" should be referred to any therapy that helps increase bone mass. Bone mass represents 80% of bone mechanical strength.
Vishal Gupta, Mitul Abhaykumar Shah, Sagar Kirtibhai Shah, Jinen Mukeshbhai Shah   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness [PDF]

, 2019
Objectives To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity.
Adelantado-Renau, Mireia, Aguilera, Concepción M., Cadenas-Sanchez, Cristina, Gil-Cosano, Jose J., Gracia-Marco, Luis, Gómez Vida, José, Jürimäe, Jaak, LABAYEN , IDOIA, Maldonado, José, Mora González, José, Ortega, Francisco B, Plaza Florido, Abel Adrian, Ubago-Guisado, Esther   +12 more
core   +1 more source

A 10-Year Summary of Health Fair Data from Lakota, Powwows, and Red Shawl Events in the Rural Midwest

Obesities
Objectives—Health screening data were collected from participants at Native American community and celebratory events to evaluate their health status and identify common health concerns.
Trina Aguirre
doaj   +1 more source