Results 111 to 120 of about 1,515,008 (404)

Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein

Journal of Cell Biology, 1984
Acetylated-low density lipoprotein (Ac-LDL) is taken up by macrophages and endothelial cells via the "scavenger cell pathway" of LDL metabolism. In this report, aortic and microvascular endothelial cells internalized and degraded 7-15 times more [125I ...
J. Voyta, D. P. Via, C. E. Butterfield, B. Zetter   +3 more
semanticscholar   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Serum lipoprotein accumulation in the livers of orotic acid-fed rats

Journal of Lipid Research, 1971
This study provides confirmation of previous observations that showed that rats fed a diet containing 1% orotic acid for 7 days develop a fatty liver and that there is an inhibition of the secretion of low density lipoproteins without altering general ...
LAWRENCE A. POTTENGER, GODFREY S. GETZ
doaj   +1 more source

Oscillating shear index, wall shear stress and low density lipoprotein accumulation in human RCAs

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
Soulis, JV, Giannoglou, GD, Fytanidis, DK, Papaioannou, VC, 3rd Micro and Nano Flows Conference (MNF2011)   +4 more
core  

Protein and cell therapy for lecithin-cholesterol acyltransferase (LCAT) deficiency [PDF]

, 2009
Lecithin-cholesterol acyltransferase (LCAT) is an enzyme principally secreted by the liver into the circulation where it esterifies cholesterol and plays a key role in high- density lipoprotein (HDL) metabolism. In familial and acquired (liver disease)
Low, J K, Low, J.K.
core  

Influence of different fat emulsions with 10 or 20% MCT/LCT or LCT on lipoproteins in plasma of patients after abdominal surgery [PDF]

, 1998
In patients after elective abdominal surgery, different fat emulsions were used to compare their efficacy in total parenteral nutrition and in normalizing plasma lipoprotein levels.
Jauch, Karl-Walter, Wolfram, Günther, Hailer, Susanne   +2 more
core   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Association of Hypertensive Retinopathy with different serum lipid parameters in patients of Essential Hypertension: A Hospital Based Study

Journal of Nobel Medical College, 2018
Introduction: Abnormalities in serum lipid and lipoprotein levels are recognized as major modifiable risk factors for cardiovascular disease and essential hypertension and retinopathy.
Bishwa Nath Adhikari, Pramod Sharma Gautam, Binod Bekoju, Sadhana Basnet, Himlal Bhandari   +4 more
doaj   +1 more source

Classification and Prediction of Low-Density Lipoprotein Cholesterol LDL-C in The Palestinian Patients Using Machine Learning Techniques

, 2021
Sanad Malaysha, Mohammed Awad, Rami Hadrob, B Ference, H Ginsberg, I Graham, K Ray, C Packard, E Bruckert, A Catapano, M Vrbaki, R Doroslovaki, A Kupusinac, E Stoki, D Iveti, V Carey, L Bishop, N Laranjo, B Harshfield, C Kwiat, F Sacks, P Thaisiam, J Sothornwit, S Charoensri, S Pattanapairoj, P Kotruchin, C Pongchaiyakul, T Lee, J Kim, Y Uh, H Lee, J Wiens, E Shenoy, J Ma, J Yu, G Hao, D Wang, Y Sun, J Lu, F Lin, S Mohan, C Thirumalai, G Srivastava, T Lee, J Kim, Y Uh, H Lee, R Wadhera, D Steen, I Khan, R Giugliano, J Foody, T Bathen, J Krane, T Engan, K Bjerve, D Axelson, J Liu, Y Chen, L Lan, B Lin, W Chen, M Wang, Y Duan, I Hamdan, M Awad, W Sabbah, H Qteat, M Awad, A Schein, L Ungar, A Alabdallah, M Awad, S Suthaharan, Y Song, L Ying, H Sak, A Senior, F Beaufays, S Li, W Li, C Cook, C Zhu, Y Gao, M Awad, A Abuhasan, M Awad, I Qasrawi, M Awad, J Jang   +89 more
openalex   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source