Results 161 to 170 of about 10,449,342 (203)

Low-density lipoprotein oxidation.

Italian heart journal : official journal of the Italian Federation of Cardiology, 2001
Free radical mediated oxidation of low-density lipoproteins (LDL), which has been extensively studied in the last two decades, plays a central role in the development of the atherosclerotic plaque. Oxidation involves the lipid moiety of LDL in a chain reaction mechanism.
IULIANO, Luigi, MICHELETTA F, VIOLI, Francesco   +2 more
openaire   +2 more sources

Modified Low-Density Lipoproteins and High-Density Lipoproteins

Pathophysiology of Haemostasis and Thrombosis, 2006
It has long been known that the oxidative state of the various plasma lipoproteins modulates platelet aggregability, thereby contributing to atherogenesis. Low-density lipoprotein (LDL), occurring in vivo both in the native and oxidised forms, interacts directly with platelets, by binding to specific receptors.
Elisabeth Koller, Ivo Volf, Aner Gurvitz, Franz Koller   +3 more
openaire   +1 more source

Low-density Lipoproteins in Atherogenesis

2000
It is well established that high levels of plasma cholesterol, particularly those associated with low-density lipoprotein (LDL), increase the risk of developing atherosclerosis. It is also clear that lowering plasma cholesterol levels can arrest or even reverse the progression of the disease [1,2].
openaire   +1 more source

Inhibition of Low-Density Lipoprotein and High-Density Lipoprotein Oxidation by Raloxifene

Journal of Women's Health, 2004
Raloxifene (RX), a selective estrogen receptor modulator (SERM), has demonstrated hypolipidemic and in vitro antioxidant properties. In the pathogenesis of atherosclerosis, the oxidative modification of low-density lipoprotein (LDL) is implicated to play a crucial role.In this study, we investigated the antioxidant properties of RX during in vitro LDL ...
Ulrike, Resch, Viktoria, Mellauner, Alexandra, Budinsky, Helmut, Sinzinger   +3 more
openaire   +2 more sources

Atherosclerosis regression: Is low-density lipoprotein or high-density lipoprotein the answer?

Current Atherosclerosis Reports, 2007
Lowering low-density lipoprotein cholesterol is the cornerstone of risk modification in patients with established coronary artery disease. Considerable attention is currently focused on developing pharmacologic agents that promote the biologic activity of high-density lipoprotein.
Stephen J, Nicholls, E Murat, Tuzcu, Steven E, Nissen   +2 more
openaire   +2 more sources

High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990
Oxidatively modified low-density lipoprotein (LDL), generated as a result of incubation of LDL with specific cells (e.g., endothelial cells, EC) or redox metals like copper, has been suggested to be an atherogenic form of LDL. Epidemiological evidence suggests that higher concentrations of plasma high-density lipoprotein (HDL) are protective against ...
S, Parthasarathy, J, Barnett, L G, Fong
openaire   +2 more sources

Antioxidant effect of high-density lipoproteins in peroxidation of low-density lipoproteins

Bulletin of Experimental Biology and Medicine, 1987
It has been shown that in the solution of low density lipoproteins (LDL) during their incubation at 37 degrees C the turbidity and concentration of malondialdehyde was increased, as compared to that observed at 4 degrees C. Both parameters were slowed down by the addition of high density lipoproteins (HDL) into the medium.
A N, Klimov, L A, Kozhemiakin, V M, Pleskov, L I, Andreeva   +3 more
openaire   +2 more sources

Low-Density Lipoprotein Density and Atherosclerosis

JAMA, 1994
To provide an overview of the relationship between low-density lipoprotein (LDL) density and coronary artery disease and to examine this relationship in terms of lipid peroxidation and the atherogenic remnant hypothesis.English-language studies and reviews pertaining to LDL composition and size were identified through a MEDLINE search and reference ...
openaire   +2 more sources

Receptors for modified low-density lipoproteins on human endothelial cells: different recognition for acetylated low-density lipoprotein and oxidized low-density lipoprotein

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1991
We examined the uptake pathway of acetylated low-density lipoprotein and oxidatively modified LDL (oxidized LDL) in human umbilical vein endothelial cells in culture. Proteolytic degradation of 125I-labeled Ac-LDL or Ox-LDL in the confluent monolayer of human endothelial cells was time-dependent and showed saturation kinetics in the dose-response ...
N, Kume, H, Arai, C, Kawai, T, Kita
openaire   +2 more sources

Circulating low density lipoprotein (LDL)

Hormone Molecular Biology and Clinical Investigation, 2018
Abstract Low-density lipoprotein (LDL) particles are known as atherogenic agents in coronary artery diseases. They modify to other electronegative forms and may be the subject for improvement of inflammatory events in vessel subendothelial spaces. The circulating LDL value is associated with the plasma PCSK-9 level.
Mohsen, Khosravi, Reza, Hosseini-Fard, Mohammad, Najafi   +2 more
openaire   +2 more sources