Results 211 to 220 of about 10,612,844 (305)

Low-grade Central Osteosarcoma with High-grade Transformation in the Distal Tibia: A Rare Case Report. [PDF]

J Orthop Case Rep
Patel T, Singh G, Bhankhodia V, Dangar AM, Thesiya Y, Gupta A.   +5 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Detection of Turbulent Combustion Mechanism in NH3/H2 Stratified Premixtures Using Chemical Explosive Mode Analysis

ACS Omega
Yinhu Kang, Jiuyi Zhang, Wenxuan Zhou, Haoran Wang, Xiaomei Huang, Xiaofeng Lu   +5 more
doaj   +1 more source

Mechanical Small Bowel Obstruction Secondary to Low-Grade Appendiceal Mucinous Neoplasm: A Case Report. [PDF]

Cureus
Rojas Guanoluisa SA, García Romero JM, Alcalá Ochoa E, Morales Rubio A, Castaneda-Cardoso Y.   +4 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Mebendazole Shows Antiproliferative and Antimigratory Effects in Paediatric Low-Grade Glioma Models. [PDF]

Oncol Res
Ferraro C, Pizzoferrato M, Graziano M, Servidei T, Ruggiero A, Navarra P, Lisi L.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Synchronous Low-Grade Appendiceal Mucinous Neoplasm and Neuroendocrine Tumor Presenting as Pseudomyxoma Peritonei: A Case Report. [PDF]

Cureus
Stevens T, Fleury L, Collera J, Jagodzinski K, Fan J.   +4 more
europepmc   +1 more source

Intraoperative electrical stimulation in awake craniotomy: methodological aspects of current practice

, 2010
FEIGL GC, DUFFAU H, BELLO L, FAVA E, NEULOH F, SZELÉNY A, SALA F. WORKGROUP FOR INTRAOPERATIVE MANAGEMENT IN LOW GRADE GLIOMA SURGERY WITHIN THE EUROPEAN LOW-GRADE GLIOMA NETWORK, SIGNORELLI F, GALANDA M   +8 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source