Results 1 to 10 of about 20,216 (144)

Clinical manifestation and genetic findings in three boys with low molecular Weight Proteinuria - three case reports for exploring Dent Disease and Fanconi syndrome [PDF]

BMC Nephrology, 2021
Background Dent disease is an X-linked form of progressive renal disease. This rare disorder was characterized by hypercalciuria, low molecular weight (LMW) proteinuria and proximal tubular dysfunction, caused by pathogenic variants in CLCN5 (Dent ...
Nan Duan, Chenwei Huang, Lu Pang, Shiju Jiang, Wenshuang Yang, Haixia Li   +5 more
doaj   +2 more sources

Prevalence of low molecular weight proteinuria and Dent disease 1 CLCN5 mutations in proteinuric cohorts. [PDF]

Pediatr Nephrol, 2020
Dent disease type 1 (DD1) is a rare X-linked disorder caused mainly by CLCN5 mutations. Patients may present with nephrotic-range proteinuria leading to erroneous diagnosis of focal segmental glomerulosclerosis (FSGS) and unnecessary immunosuppressive treatments.The following cohorts were screened for CLCN5 mutations: Chronic Kidney Disease in Children
Beara-Lasic L, Cogal A, Mara K, Enders F, Mehta RA, Haskic Z, Furth SL, Trachtman H, Scheinman SJ, Milliner DS, Goldfarb DS, Harris PC, Lieske JC, investigators of the Rare Kidney Stone Consortium.   +13 more
europepmc   +4 more sources

The Spectrum of Kidney Diseases in Children Associated with Low Molecular Weight Proteinuria. [PDF]

Open Access Maced J Med Sci, 2018
BACKGROUND: Proteinuria, in addition to haematuria, is the most important laboratory parameter in patients with nephro-urological diseases. Low molecular weight proteinuria (LMWP) is of particular importance because some diseases genetic and tubulointerstitial are diagnosed based on its presence.AIM: The purpose of this study is to describe the ...
Salihu S, Tosheska K, Aluloska N, Gucev Z, Cekovska S, Tasic V.   +5 more
europepmc   +4 more sources

Unprecedented coexistence of Dent’s disease type 1 and Wilson’s disease in a two-year-old Chinese boy: implications for precision medicine [PDF]

BMC Nephrology
Background The concurrent diagnosis of Dent’s disease type 1 (DD1) and Wilson’s disease (WD) in a single individual has not been previously documented. The co-occurrence of these two distinct autosomal recessive and X-linked disorders poses significant ...
Qingxian Mao, Wai W. Cheung, Ruochen Che, Fei Zhao, Xueqin Cheng, Guixia Ding   +5 more
doaj   +2 more sources

Clinical and Genetic Insights Into Isolated Proteinuria With CUBN Variants [PDF]

Kidney International Reports
Introduction: Cubilin is a multiligand receptor essential for vitamin B12 uptake in the small intestine and for low–molecular-weight protein reabsorption in the proximal tubule.
Nana Sakakibara, Shinya Ishiko, Yu Tanaka, Yuta Inoki, Yuta Ichikawa, Hideaki Kitakado, Chika Ueda, Atsushi Kondo, Yuya Aoto, Tomoko Horinouchi, Tomohiko Yamamura, Shingo Ishimori, Chinatsu Onodera, Aya Inaba, Riku Hamada, Yutaka Harita, China Nagano, Kandai Nozu   +17 more
doaj   +2 more sources

Electrophoretic analysis (sds-page) of canine urinary proteins according to the stage of chronic kidney disease [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2020
Glomerular proteinuria is characterized by the loss of high-molecular-weight proteins (HMWPs), while tubulointerstitial proteinuria is characterized by the loss of low-molecular-weight proteins (LMWPs). The objective was to assess the molecular weight of
L.T. Patitucci, M.V. Azeredo, M.A. Verícimo, N.R.P. Almosny, M.C.N. Castro   +4 more
doaj   +1 more source

Terahertz spectra of proteinuria and non-proteinuria

Frontiers in Bioengineering and Biotechnology, 2023
In clinical practice, proteinuria detection is of great significance in the diagnosis of kidney diseases. Dipstick analysis is used in most outpatient settings to semi-quantitatively measure the urine protein concentration.
Zhenrui Xue, Ping Mao, Ping Mao, Ping Peng, Shihan Yan, Shihan Yan, Ziyi Zang, Chunyan Yao   +7 more
doaj   +1 more source

Dent Disease Type 2 as a Cause of Focal Segmental Glomerulosclerosis in a 6-Year-Old Boy: A Case Report

Frontiers in Pediatrics, 2020
Dent disease is an X-linked recessive renal tubular disorder characterized by proximal tubule dysfunction. Typical features include low molecular weight proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis, rickets, and chronic renal failure ...
Martin Bezdíčka, Jan Langer, Jaromír Háček, Jakub Zieg   +3 more
doaj   +1 more source

Neonatal Proteinuria in Calves—A Quantitative Approach

Animals, 2021
Urine testing is a convenient, non-invasive method of obtaining information about body functions. Depending on the intended purpose, urine testing may be qualitative and/or quantitative. Urine analysis can also include proteins.
Wiesław Skrzypczak, Alicja Dratwa-Chałupnik, Małgorzata Ożgo, Karolina Boniecka   +3 more
doaj   +1 more source

Comparative Study of Fucoidan from Saccharina japonica and Its Depolymerized Fragment on Adriamycin-Induced Nephrotic Syndrome in Rats

Marine Drugs, 2020
Nephrotic syndrome (NS) is a clinical syndrome with a variety of causes, mainly characterized by heavy proteinuria, hypoalbuminemia, and edema. At present, identification of effective and less toxic therapeutic interventions for nephrotic syndrome ...
Jiaojiao Tan, Jing Wang, Lihua Geng, Yang Yue, Ning Wu, Quanbin Zhang   +5 more
doaj   +1 more source