Results 41 to 50 of about 629,370 (259)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Calf circumference as a surrogate indicator for detecting low muscle mass in hospitalized geriatric patients. [PDF]

BACKGROUND Sarcopenia is characterized by low muscle strength, decreased muscle mass, and decline in physical performance. While the measurements of muscle strength and physical performance are easy to perform, an accurate evaluation of muscle mass is
Kressig, Reto W., Kiss, Caroline M, Beerli, Nadine, Fischer, Andreas, Bertschi, Dominic, Kressig, Reto W, Fischer, Andreas M, Kiss, Caroline M., Berres, Manfred   +8 more
core   +1 more source

Body mass index, muscle strength and physical performance in older adults from eight cohort studies: the HALCyon programme. [PDF]

, 2013
Objective To investigate the associations of body mass index (BMI) and grip strength with objective measures of physical performance (chair rise time, walking speed and balance) including an assessment of sex differences and non-linearity.
Hardy, R, John M. Starr (107707), McNeill Geraldine, Cooper, R, Kuh Diana, Rachel Cooper, Gallacher, John, Holly Syddall, Geraldine McNeill, Starr, John M., John Gallacher, Starr, John M, Yoav Ben-Shlomo, Aihie Sayer, Avan, McNeill, G, Ben-Shlomo, Y, Cyrus Cooper (141250), Panayotes Demakakos (196562), John Gallacher (196569), Martin, Richard M, Syddall Holly, Cyrus Cooper, Cooper Cyrus, Martin, RM, Hardy, Rebecca, Steptoe Andrew, McNeill, Geraldine, Demakakos, Panayotes, Demakakos Panayotes, Starr, JM, Syddall, H, Steptoe, A, ?, ?, John M Starr, HALCyon study team, Avan Aihie Sayer, Geraldine McNeill (107695), Cooper, Rachel, Deary, IJ, Ben-Shlomo, Yoav, Ian J. Deary (107724), Cooper Rachel, Avan Aihie Sayer (188916), Rebecca Hardy, Hardy Rebecca, Deary, Ian J., Martin, Richard M., Ian J Deary, Cooper, Cyrus, Holly Syddall (231862), Syddall, Holly, Richard M. Martin (176602), Sayer, Avan Aihie, Kuh, Diana, Rebecca Hardy (188906), Gallacher, J, Deary, Ian J, Panayotes Demakakos, Martin Richard M., Demakakos, P, Richard M Martin, Yoav Ben-Shlomo (95286), Andrew Steptoe, Diana Kuh, Gallacher John, Kuh, D, Starr John M., Andrew Steptoe (36331), Deary Ian J., Aihie Sayer, A, Cooper, C, Aihie Sayer Avan, Steptoe, Andrew, Ben-Shlomo Yoav, Diana Kuh (188923), Rachel Cooper (188902)   +75 more
core   +1 more source

Impact of Low Muscle Mass and Low Muscle Strength According to EWGSOP2 and EWGSOP1 in Community-Dwelling Older People

The Journals of Gerontology: Series A, 2020
Abstract Background A universal definition of sarcopenia is still lacking. Since the European criteria have been recently revised, we aimed at studying prevalence of low muscle strength (LMS) and low muscle mass (LMM), as defined according to the European Working Group of Sarcopenia in Older People ...
Costanzo L., De Vincentis A., Di Iorio A., Bandinelli S., Ferrucci L., Antonelli Incalzi R., Pedone C.   +6 more
openaire   +4 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Muscle x-ray attenuation is not decreased during experimental bed rest.

, 2013
Muscle X-ray attenuation (MXA) in Hounsfield units (HU) is decreased in dystrophy, aging, and immobilization. We hypothesized a decrease also during bed rest (BR).
Bareille, MARIE-PIERRE, Rittweger, Jörn, Felsenberg, Dieter, Müller, Klaus   +3 more
core   +1 more source