Results 61 to 70 of about 484,819 (300)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Limits of low-probability-of-detection communication over a discrete memoryless channel [PDF]

2015 IEEE International Symposium on Information Theory (ISIT), 2015
This paper considers the problem of communication over a discrete memoryless channel subject to the constraint that the probability that an adversary who observes the channel outputs can detect the communication is low. Specifically, the relative entropy between the output distributions when a codeword is transmitted and when no input is provided to ...
Ligong Wang 0002, Gregory W. Wornell, Lizhong Zheng   +2 more
openaire   +2 more sources

A Decoding Algorithm for LDPC Codes Over Erasure Channels with Sporadic Errors

, 2010
An efficient decoding algorithm for low-density parity-check (LDPC) codes on erasure channels with sporadic errors (i.e., binary error-and-erasure channels with error probability much smaller than the erasure probability) is proposed and its performance ...
Paolini, Enrico, G. Liva, Balazs Matuz, B. Matuz, Marco Chiani, Liva, Gianluigi, Chiani, Marco, Matuz, Balazs, Gianluigi Liva, Enrico Paolini   +9 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Strengthening population inference in herpetofaunal studies by addressing detection probability

, 2020
In conservation biology and population dynamic studies, accounting for the effect of imperfect detection of animals in the wild is crucial for correct inference of demographic parameters.
Munguia-Steyer, R., Doherty, P. F., Guimaraes, M.   +2 more
core   +2 more sources

NB-IoT physical random access analysis and receiver detection algorithm

Dianzi Jishu Yingyong, 2018
NB-IoT is an emerging cellular technology that provides better coverage for applications with large connectivity,low power,low throughput,low device cost and high latency tolerance.Compared with Long Term Evolution(LTE)system,the Narrow-band Physical ...
Li Xiaowen, Qu Yuanyuan, Zhou Shuqi, Mou Hongyan, Chen Qirong   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Stand-Alone, Low Probability of Detection Positioning for Small Airborne Vehicles Using Commercial SDRs

IEEE Journal of Microwaves
This paper presents the design, development, and prototyping of a stand-alone, low probability of detection (LPD) positioning network using commercially-available software-defined radios (SDRs).
Arnaldo J. Sans, John M. Willis, Charles F. Barry, Marc Weiss, Satheesh Bojja Venkatakrishnan, John L. Volakis   +5 more
doaj   +1 more source