Results 81 to 90 of about 3,354,892 (317)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Noise of a superconducting magnetic flux sensor based on a proximity Josephson junction

Scientific Reports, 2017
We demonstrate simultaneous measurements of DC transport properties and flux noise of a hybrid superconducting magnetometer based on the proximity effect (superconducting quantum interference proximity transistor, SQUIPT).
R. N. Jabdaraghi, D. S. Golubev, J. P. Pekola, J. T. Peltonen   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Publisher Correction: Nonlinear two-level dynamics of quantum time crystals

Nature Communications, 2022
S. Autti, P. J. Heikkinen, J. Nissinen, J. T. Mäkinen, G. E. Volovik, V. V. Zavyalov, V. B. Eltsov   +6 more
doaj   +1 more source

Compactive Viscosity of Snow and Its Climatic Implications at Mizuho Station, Antarctica (Special Issue of the Proceedings of the First Symposium on Antarctic Meteorology and Glaciology)

Antarctic Record, 1979
The compactive viscosity coefficient of snow was obtained from a density profile at Mizuho Station, Antarctica The value of the compactive viscosity coefficient was by two orders of magnitude larger than that of ordinary seasonal snow.
Norikazu MAENO, Hideki MAEDA
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Highly effective energy transfer in the autotroph-heterotroph symbiosis: insights from compound-specific isotope analysis of amino acids

Progress in Earth and Planetary Science
Many species establish symbiotic partnerships with different organisms to benefit energetically from living together to fit into environments, and such symbiosis is frequently found in the modern ocean as well as throughout Earth’s history.
Jincen Li, Mio Shibuya, Yuko Takizawa, Yoshito Chikaraishi   +3 more
doaj   +1 more source

Stimulated Raman adiabatic passage in a three-level superconducting circuit

Nature Communications, 2016
The precise control and manipulation of the states of a multi-level quantum system are fundamental for quantum information processing. Here, the authors demonstrate the robust adiabatic manipulation of the quantum states of a superconducting circuit via ...
K. S. Kumar, A. Vepsäläinen, S. Danilin, G. S. Paraoanu   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The order of magnetic phase transitions in disordered double perovskite oxides Sm2FeCoO6 and Dy2FeCoO6

AIP Advances, 2018
We present the results on the order of phase transition around the spin re-orientation region using isothermal magnetization data performed on the sol-gel synthesized disordered double perovskite oxides Sm2FeCoO6 and Dy2FeCoO6 by Arrott plot method.
G. R. Haripriya, R. Pradheesh, K. Sethupathi, V. Sankaranarayanan   +3 more
doaj   +1 more source