Results 101 to 110 of about 499,765 (280)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Organic Single-Crystal Field-Effect Transistors
, 2004 We present an overview of recent studies of the charge transport in the field effect transistors on the surface of single crystals of organic low-molecular-weight materials.
de Boer, R. W. I. +3 more
core +2 more sources
IEEE Open Journal of the Industrial Electronics SocietyHigh-gain dc–dc converters are used for a number of applications including the power processing of several low-voltage renewable energy sources (solar photovoltaic and fuel cells) while they are integrated into a microgrid. This article introduces
Md Samiullah +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Pineapples internal quality inspection approaches and its potential effects in Malaysia [PDF]
, 2020 Pineapple (Ananas Comosus L. Metil) is a tropical plant under Bromeliaceous family that is grown in American tropics, subtropics, and warmer regions (U. Nations 2012). Pineapple is the second harvest tropical fruit after banana in the world (S.
Jam, Mohamad Nur Hakim +2 more
core
Single-Stage Non-Isolated High Conversion Ratio Step-Down Converter for Voltage Regulation Modules
IEEE Open Journal of Power ElectronicsThis paper proposes a non-isolated converter with an ultra-high step-down voltage conversion ratio and low voltage stress on switching devices, achieved within a moderate duty cycle for voltage regulation modulators (VRMs).
Dinh Phuc Nguyen +3 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The effect of diffusion induced lattice stress on the open-circuit voltage in silicon solar cells [PDF]
It is demonstrated that diffusion induced stresses in low resistivity silicon solar cells can significantly reduce both the open-circuit voltage and collection efficiency.
Godlewski, M. P., Weizer, V. G.
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Energies, 2018 Bridgeless power factor correction (PFC) converters have a reduced number of semiconductors in the current flowing path, contributing to low conduction losses.
Xiang Lin +2 more
doaj +1 more source