Results 91 to 100 of about 996,357 (278)
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Известия Иркутского государственного университета: Серия "Математика", 2016 The representations, including polynomial, of functions over final fields have been actively investigated. The complexity of such representations is the main stream of research.
A. Baliuk, A.S. Zinchenko
doaj
Some characterizations of error bound for non-lower semicontinuous functions
Journal of Inequalities and Applications, 2019 In this paper, we study the error bound of non-lower semicontinuous functions. First, we extend the concepts of strong slope and global slope to the non-lower semicontinuous functions.
Miantao Chao +2 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Journal of Topology, 2018 We prove a new lower bound for the dilatation of an arbitrary pseudo-Anosov map on a surface of genus g with n punctures. Our bound improves the former super-exponential dependence on the genus by a polynomial dependence.
openaire +5 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
, 2015 Distance upper-bounding DUB allows a verifier to know whether a proving party is located within a certain distance bound. DUB protocols have many applications in secure authentication and location based services. We consider the dual problem of distance lower bounding DLB, where the prover proves it is outside a distance bound to the verifier.
Xifan Zheng +2 more
openaire +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Generalized weights and bounds for error probability over erasure channels [PDF]
, 2014 New upper and lower bounds for the error probability over an erasure channel are provided, making use of Wei's generalized weights, hierarchy and spectra.
Firer, Marcelo, Lemes, Leandro Cruvinel
core
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source