Results 101 to 110 of about 1,003,788 (328)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
, 2015 Distance upper-bounding DUB allows a verifier to know whether a proving party is located within a certain distance bound. DUB protocols have many applications in secure authentication and location based services. We consider the dual problem of distance lower bounding DLB, where the prover proves it is outside a distance bound to the verifier.
Xifan Zheng +2 more
openaire +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Refined universality for critical KCM: lower bounds [PDF]
, 2022 Ivailo Hartarsky, Laure Marêché
openalex +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Lower Bounds on Signatures from Symmetric Primitives [PDF]
, 2019 We show that every construction of one-time signature schemes from a random oracle achieves black-box security at most $2^{(1+o(1))q}$, where $q$ is the total number of oracle queries asked by the key generation, signing, and verification algorithms ...
Barak, Boaz, Mahmoody, Mohammad
core +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Lower Bounds and Semi On-line Multiprocessor Scheduling [PDF]
Computer Science Journal of Moldova, 2003 We are given a set of identical machines and a sequence of jobs from which we know the sum of the job weights in advance. The jobs have to be assigned on-line to one of the machines and the objective is to minimize the makespan.
T.C. Edwin Cheng +2 more
doaj
Lower Bounds on Anderson-Localised Eigenfunctions on a Strip. [PDF]
Commun Math Phys, 2022 Goldsheid I, Sodin S.
europepmc +1 more source