Results 101 to 110 of about 996,357 (278)

Kernelization Lower Bounds By Cross-Composition

, 2012
We introduce the cross-composition framework for proving kernelization lower bounds. A classical problem L AND/OR-cross-composes into a parameterized problem Q if it is possible to efficiently construct an instance of Q with polynomially bounded ...
Bodlaender, Hans L., Jansen, Bart M. P., Kratsch, Stefan   +2 more
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Lower Bounds of Blow-Up Time for Certain Fractional Diffusion Equations and Systems with Nonlinear Memory Terms in Bounded Domains

Fractal and Fractional
In this paper, we prove the lower bounds of the blow-up time of solutions for certain Caputo time fractional diffusion equations and systems with nonlinear memory terms under homogeneous Dirichlet boundary conditions.
Quanguo Zhang, Yaning Li
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Lower Bounds on Anderson-Localised Eigenfunctions on a Strip. [PDF]

Commun Math Phys, 2022
Goldsheid I, Sodin S.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Lower Bounds and Semi On-line Multiprocessor Scheduling [PDF]

Computer Science Journal of Moldova, 2003
We are given a set of identical machines and a sequence of jobs from which we know the sum of the job weights in advance. The jobs have to be assigned on-line to one of the machines and the objective is to minimize the makespan.
T.C. Edwin Cheng, Hans Kellerer, Vladimir Kotov   +2 more
doaj  

Erratum to “Lower Bounds for Some Factorable Matrices”

International Journal of Mathematics and Mathematical Sciences, 2007
The purpose of this erratum is to correct both the mathematical and typographical errors made in 2006.
B. E. Rhoades, Pali Sen
doaj   +1 more source

Lower Bounds on Multivariate Higher Order Derivatives of Differential Entropy. [PDF]

Entropy (Basel), 2022
Guo L, Yuan CM, Gao XS.
europepmc   +1 more source