Results 131 to 140 of about 1,003,788 (328)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Sensitivity Analysis for Binary Sampling Systems via Quantitative Fisher Information Lower Bounds [PDF]

, 2015
Manuel Stein
openalex   +1 more source

On Lower Bounds for Standard and Robust Gaussian Process Bandit\n Optimization [PDF]

, 2020
Xu Cai, Jonathan Scarlett
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Space Lower Bounds for the Signal Detection Problem. [PDF]

Theory Comput Syst, 2021
Ellen F, Gelashvili R, Woelfel P, Zhu L.
europepmc   +1 more source

Estimating upper and lower bounds on the performance of word-sense disambiguation programs [PDF]

, 1992
William A. Gale, Kenneth Church, David Yarowsky   +2 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Lower bounds for the blowup time of solutions to a nonlinear parabolic problem

Electronic Journal of Differential Equations, 2014
In this short article, we study the blow-up properties of solutions to a parabolic problem with a gradient nonlinearity under homogeneous Dirichlet boundary conditions.
Haixia Li, Wenjie Gao, Yuzhu Han
doaj  

Tight analyses for subgradient descent I: Lower bounds

Open Journal of Mathematical Optimization
Consider the problem of minimizing functions that are Lipschitz and convex, but not necessarily differentiable. We construct a function from this class for which the $Tþ$ iterate of subgradient descent has error $\Omega (\log (T)/\sqrt{T})$. This matches
Harvey, Nicholas J. A., Liaw, Chris, Randhawa, Sikander   +2 more
doaj   +1 more source

Epsilon regularity under scalar curvature and entropy lower bounds and volume upper bounds [PDF]

, 2022
Robin Neumayer
openalex   +1 more source