Results 41 to 50 of about 2,259,033 (298)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Citizenship development of adolescents during the lower grades of secondary education [PDF]

Journal of Adolescence, 2015
ABSTRACTThe present study focuses on the development of citizenship competences of Dutch adolescents, including the political and social aspects as part of adolescents' daily lives. We followed 5070 adolescents aged 12–16 years across a three‐year period in lower secondary education.
Geboers, E., Geijsel, F., Admiraal, W., Jorgensen, T., ten Dam, G.   +4 more
openaire   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Zkrácená škála kognitivního uzavření: struktura české verze u vzorku studentů učitelství a učitelů

Orbis Scholae, 2019
The Need for Closure Scale – NFCS (Roets & Van Hiel, 2011) was designed to assess individuals’ motivation with respect to information processing and judgement. The need for closure is defined as a desire for an answer in order to stop further information
Kateřina Vlčková, Stanislav Ježek, Tomáš Kohoutek, Jan Mareš   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Physical Activity Behavior in Swiss Secondary School Students: A Segmented Analysis

Current Issues in Sport Science
Introduction Physical activity (PA) levels decline from childhood to adolescence, and many Swiss adolescents do not achieve the WHO's recommendation of 60 minutes of daily moderate-to-vigorous physical activity (MVPA) (Bringolf-Isler et al. 2016).
Marion Gasser, Andrea-Maria Nadenbousch, Fabienne Egger, Mario Kamer, Stefan Valkanover, Mirko Schmidt   +5 more
doaj   +1 more source

Physics Education in the Lower Secondary Schools of Austria in Connection with Elementary Science Education [PDF]

, 2007
オーストリアの前期中等教育段階における物理教育の現状を、前段階である初等教育段階の科学(理科)教育との関連性の視座に立ち、学習指導要領、教科書などから、明らかにした。オーストリアの前期中等教育段階における物理教育は、独立した教科書を設けて行われている。一方、初等教育段階における物理教育は、「事象教授」の枠内で行われているとみなせる。学習目標は両段階とも知識理解だけに限定していない点で共通しているが、その性格や範囲が異なっている。学習内容に至っては、前期中等教育段階では思考方法 ...
Tanaka, Kenji
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Schriftliche Sprachmittlung in Zeiten Künstlicher Intelligenz – eine empirische Erhebung mit Spanischlernenden der Sekundarstufe I

Journal of Linguistics and Language Teaching
(Deutsch) Der Einsatz von KI-Anwendungen im Rahmen von Sprachmittlungsaktivitäten im Fremdsprachenunterricht ist mit neuen Chancen und Herausforderungen verbunden, die die Notwendigkeit von KI-spezifischen Kompetenzen auf Seiten der Lernenden ...
Johanna Lea Korell, Maximilian Irion, Roland Ißler   +2 more
doaj   +1 more source