Results 61 to 70 of about 2,270,674 (298)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Educational pathways of minority youth in Norway : intersections of gender, ethnicity and social class [PDF]
, 2007 Educational aspirations during lower secondary school and choice of upper secondary education are important for young people's future trajectories into higher education and labour market positions.
Smette, Ingrid +1 more
core +4 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Evaluating the effects of labour market reforms at the margin on unemployment and employment stability: the Spanish case [PDF]
, 2005 This study analyses the effects on unemployment and the quality of employment of the Spanish labour market reform in 2001 for the most important age groups.
Arellano, F. Alfonso
core +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
When and where to intervene: identifying key school segments to enhance adolescent physical activity
Frontiers in Sports and Active LivingBackgroundSwiss adolescents fall short of the WHO's guideline of 60 min of moderate-to-vigorous physical activity (MVPA) per day. Developing targeted interventions or policies requires an understanding of adolescents’ daily activity patterns.
Marion Gasser +8 more
doaj +1 more source
Early school-leaving in the Netherlands [PDF]
The role of student-, family- and school factors for early school-leaving in lower secondary educationMost studies on early school-leaving address only partial causes of why some students leave school early.
Traag Tanja, Velden Rolf K.W. van der
core +1 more source
Violence in schools: what are the lessons for teacher education?
Ensaio, 2018 Considering that teachers play a fundamental role in overcoming violence in schools, this research identified adolescents’ perceptions of their teachers’ actions. The qualitative investigation involved immersion in a government-run lower secondary school
Adriana Lira, Candido Alberto Gomes
doaj +1 more source