Results 51 to 60 of about 2,270,674 (298)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Objects, Tools, and Cooperation Arrangements in Intensified Personal Guidance Counseling in Finland

Nordic Journal of Transitions, Careers and Guidance
Career guidance as an institutionalized pedagogical practice carries a range of aspirations and goals aimed at supporting individuals through various transitions in education and the labor market. In this article, we examine one of the most recent policy
Anne-Mari Souto, Sanna Vehviläinen, Hanna Lonka   +2 more
doaj   +1 more source

The Socioeconomic Gap in University Dropouts [PDF]

, 2009
In many countries, including the U.S. and the U.K., there is ongoing concern about the extent to which young people from lower-income backgrounds can acquire a university degree. Recent evidence from the U.K.
Powdthavee, Nattavuudh, Vignoles, Anna
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The role of the teacher of Italian in the new curriculum of “Educazione civica”

Italiano a scuola, 2021
This contribution proposes some teaching units that can be developed by the teacher of Italian in the lower secondary schools within the new curriculum of “Educazione civica”.
Cecilia Demuru
doaj   +1 more source

Importance of physical health and health-behaviors in adolescence for risk of dropout from secondary education in young adulthood: an 8-year prospective study [PDF]

, 2015
Education and health constitute two interlinked assets that are highly important to individuals. In Iceland, prevalence of dropout from secondary education poses a considerable problem.
Arngrímsson, Sigurbjörn Árni, Johannesson, Erlingur, Svansdottir, Erla, Sveinsson, Thorarinn   +3 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Lost in Transition? The returns to education acquired under communism 15 years after the fall of the Berlin Wall [PDF]

Using data for 23 economies in Eastern and Western Europe, we find evidence that having studied under communism is relatively penalized in the economies of the late 2000s. This evidence, however, is limited to males and to primary and secondary education,
Elena Crivellaro, Giorgio Brunello, Lorenzo Rocco   +2 more
core   +3 more sources

Regula falsi in lower secondary school education

Teaching Mathematics and Computer Science, 2016
The aim of this paper is to offer some possible ways of solving word problems in lower secondary school education. Many studies have shown that pupils in lower secondary school education (age 13-14) encounter difficulties with learning algebra. Therefore they mainly use arithmetical and numerical checking methods to solve word problems.
openaire   +1 more source