Results 41 to 50 of about 2,270,674 (298)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Fail, flip, fix, feed: impact on engagement and learning outcomes

Frontiers in Education
BackgroundFlipped classrooms and productive failure foster active learning by reversing the traditional sequence of instruction and problem-solving. Despite strong evidence for each approach in secondary mathematics, their combined implementation remains
Richard Conrardy, Richard Conrardy, Christian Spannagel, Sabou Rani Stocker   +3 more
doaj   +1 more source

Citizenship development of adolescents during the lower grades of secondary education [PDF]

Journal of Adolescence, 2015
ABSTRACTThe present study focuses on the development of citizenship competences of Dutch adolescents, including the political and social aspects as part of adolescents' daily lives. We followed 5070 adolescents aged 12–16 years across a three‐year period in lower secondary education.
Geboers, E., Geijsel, F., Admiraal, W., Jorgensen, T., ten Dam, G.   +4 more
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Physical Activity Behavior in Swiss Secondary School Students: A Segmented Analysis

Current Issues in Sport Science
Introduction Physical activity (PA) levels decline from childhood to adolescence, and many Swiss adolescents do not achieve the WHO's recommendation of 60 minutes of daily moderate-to-vigorous physical activity (MVPA) (Bringolf-Isler et al. 2016).
Marion Gasser, Andrea-Maria Nadenbousch, Fabienne Egger, Mario Kamer, Stefan Valkanover, Mirko Schmidt   +5 more
doaj   +1 more source

Zkrácená škála kognitivního uzavření: struktura české verze u vzorku studentů učitelství a učitelů

Orbis Scholae, 2019
The Need for Closure Scale – NFCS (Roets & Van Hiel, 2011) was designed to assess individuals’ motivation with respect to information processing and judgement. The need for closure is defined as a desire for an answer in order to stop further information
Kateřina Vlčková, Stanislav Ježek, Tomáš Kohoutek, Jan Mareš   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Schriftliche Sprachmittlung in Zeiten Künstlicher Intelligenz – eine empirische Erhebung mit Spanischlernenden der Sekundarstufe I

Journal of Linguistics and Language Teaching
(Deutsch) Der Einsatz von KI-Anwendungen im Rahmen von Sprachmittlungsaktivitäten im Fremdsprachenunterricht ist mit neuen Chancen und Herausforderungen verbunden, die die Notwendigkeit von KI-spezifischen Kompetenzen auf Seiten der Lernenden ...
Johanna Lea Korell, Maximilian Irion, Roland Ißler   +2 more
doaj   +1 more source