Results 61 to 70 of about 2,259,033 (298)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Expansion without equity: an analysis of current policy on access to higher education in Brazil [PDF]

, 2006
Access to higher education in Brazil is to a large extent restricted to the higher socioeconomic groups. Public universities have limited places and entry is determined by highly competitive exams, thereby excluding those who have not had a high quality ...
McCowan, Tristan
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Higher Education attainment : the case of intergenerational transmission of education in Portugal [PDF]

, 2010
The lack of formal education and competences of the Portuguese workers is one of the biggest problems of the country. This lack is disappearing as quickly as desired and the young generations still lag far behind those in other OECD countries. This paper
Pereira, Pedro Telhado
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Violence in schools: what are the lessons for teacher education?

Ensaio, 2018
Considering that teachers play a fundamental role in overcoming violence in schools, this research identified adolescents’ perceptions of their teachers’ actions. The qualitative investigation involved immersion in a government-run lower secondary school
Adriana Lira, Candido Alberto Gomes
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Integrating project-based and experiential learning for lower secondary competencies: A mixed-methods study

Research and Development in Education
Project-Based Learning (PjBL) is widely promoted for fostering higher-order thinking, collaboration, and problem-solving, yet its application in lower secondary schools often encounters issues of fluctuating motivation and uneven engagement. This study
Siti Zaenab, Lise Chamisijatin, S. Sukarsono, Diani Fatmawati   +3 more
doaj   +1 more source

No locality left behind? Structural and institutional drivers of eighth-grade achievement and early human capital development in Romania [PDF]

Revista de Știinţe Educaţiei
This study explores the structural and institutional determinants of early human capital formation in Romania, from a territorial perspective. The paper focuses on educational performance measured at the lowest administrative and territorial unit in ...
Ștefan-Marius DEACONU, Alina ROINIȚĂ
doaj   +1 more source

Early school-leaving in the Netherlands [PDF]

The role of student-, family- and school factors for early school-leaving in lower secondary educationMost studies on early school-leaving address only partial causes of why some students leave school early.
Traag Tanja, Velden Rolf K.W. van der
core   +1 more source