Results 71 to 80 of about 2,259,033 (298)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

When AI only asks: how question-driven dialogue shapes prewriting in the classroom

Frontiers in Education
Generative artificial intelligence has altered the conditions under which pupils learn to write, raising concerns that the slow, effortful work of idea generation and elaboration may be bypassed when fluent text can be produced instantly.
Anne Katrine Westbye, Harald Eriksen, Marte Blikstad-Balas   +2 more
doaj   +1 more source

The Effects of Financial Education: Evidence from Finnish Lower Secondary Schools [PDF]

Economic Notes, 2017
We study the effects of a peer‐to‐peer learning environment designed for lower secondary schools that provides financial education using games, videos and other materials provided online. We exploit a quasi‐experimental setting with a control group to evaluate the effects of the learning environment and to distinguish them from the effects of a general
openaire   +3 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

When and where to intervene: identifying key school segments to enhance adolescent physical activity

Frontiers in Sports and Active Living
BackgroundSwiss adolescents fall short of the WHO's guideline of 60 min of moderate-to-vigorous physical activity (MVPA) per day. Developing targeted interventions or policies requires an understanding of adolescents’ daily activity patterns.
Marion Gasser, Andrea-Maria Nadenbousch, Andrea-Maria Nadenbousch, Fabienne Egger, Mario Kamer, Mario Kamer, Stefan Valkanover, Stefan Valkanover, Mirko Schmidt   +8 more
doaj   +1 more source

Vocational Schooling, Labor Market Outcomes, and College Entry [PDF]

This paper examines the differentiated outcomes of vocational and general secondary academic education, particularly in terms of employment opportunities, labor market earnings, and access to tertiary education in Indonesia. With data from a panel of two
Chen, Dandan
core  

Evaluating the effects of labour market reforms at the margin on unemployment and employment stability: the Spanish case [PDF]

, 2005
This study analyses the effects on unemployment and the quality of employment of the Spanish labour market reform in 2001 for the most important age groups.
Arellano, F. Alfonso
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Difference Between the Average Score at the National Assessment Examination and the Average Score in Lower Secondary School Cycle – a Comparative Analysis for Romania Between 2019-2022 [PDF]

Ovidius University Annals: Economic Sciences Series, 2023
Education is the one of the corner-stones of a society and as long as this is not consolidated in the rural environment, nothing endures. Our research aims to explore the difference between the average score from national assessment examination and the
Octavian Ceban, Ionela-Roxana Petcu, Andreea Mirica   +2 more
doaj