Results 181 to 190 of about 309,429 (287)

Nanozymes-Armed Probiotic <i>Lactobacillus plantarum</i> Coordinates Ferroptosis-like Bacterial Death for Diabetic Wound Therapy. [PDF]

Research (Wash D C)
Hou J, Fu R, Zhao M, Zou A, Wang Y, Wang Z, Xianyu Y.   +6 more
europepmc   +1 more source

Light‐Driven Quadrupedal Walking Biohybrid Robot With Antagonistic Muscle‐Rings and Inclined Joints

Advanced Robotics Research, EarlyView.
This work presents a light‐driven quadrupedal walking biohybrid robot powered by antagonistic muscle‐rings that achieve alternating walking gait. Optical training improved reproducibility of cultured muscle tissues, while caffeine treatment enhanced contractile force.
Shotaro Saito, Byeongwook Jo, Tomohiro Morita, Shota Noda, Minghao Nie, Shoji Takeuchi   +5 more
wiley   +1 more source

Intraindividual Lp(a)-Variability in a Real-World Setting

JACC: Advances
Maximilian Seidel, MD, Kamil Rosiewicz, MSc, Felix S. Seibert, MD, Moritz Anft, PhD, Ulrik Stervbo, PhD, Sebastian Bertram, MD, Benjamin Sasko, MD, Christian Ukena, MD, Nina Babel, MD, Timm H. Westhoff, MD   +9 more
doaj   +1 more source

Lipoprotein(a) in Residual Cardiovascular Risk: Measurement Challenges, Assay Standardisation, and Clinical Implications

International Journal of General Medicine
Yiwen Lu,1,&ast; Dongyang Jiang,1,&ast; Jinfeng Zhang,2 Ying Liang1 1School of Clinical Medicine, Shandong Second Medical University, Weifang, People’s Republic of China; 2School of Clinical and Basic Medicine, Shandong First Medical University ...
Lu Y, Jiang D, Zhang J, Liang Y
doaj  

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Higher whole-body and exogenous postprandial glucose oxidation in the luteal versus follicular phase in healthy females. [PDF]

Physiol Rep
Govette A, West DWD, Pettit M, Antonen E, Koussiouris A, Moore DR, Gillen JB.   +6 more
europepmc   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Apo-Transferrin Modified Natamycin-Loaded Liposomes Improve the Prognosis of Fungal Keratitis via Enhanced Antifungal and Anti-Inflammatory Activities. [PDF]

Int J Nanomedicine
Hu L, Luan J, Liu X, Zhang Z, Tong Z, Qu Y, Jiang Z, Lin J.   +7 more
europepmc   +1 more source

Lp(a) [PDF]

, 2019
openaire   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source