Results 111 to 120 of about 98,340 (281)

Single‐nucleotide polymorphisms in coronary artery disease: Biological complexity, risk architecture, and implications for precision prevention

Precision Medical Sciences, EarlyView.
This graphical summary highlights the clinical application of single‐nucleotide polymorphisms‐based risk stratification in coronary artery disease. By integrating polygenic risk with clinical assessment, imaging, and preventive strategies, genetic information enables earlier risk identification, optimized screening, and personalized lifestyle and ...
Li Dai, Mosi Chen, Jun Hu, Lei Huang, Ye Yang, Chang Chen, Ying Zhuang, Yan Pan, Bingjun Qian   +8 more
wiley   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

3D‐Printed Crosslinked Nanocellulose‐MXene Hydrogels and Aerogels with High Strength and Conductivity

Small, EarlyView.
This study presents a robust strategy for 3D printing conductive, mechanically resilient MXene–CNF composite structures using a single‐step freeze‐induced crosslinking method. The printed architectures remain stable in both wet and dry states, exhibit high electrical conductivity and mechanical strength, and demonstrate practical application in fully ...
Nuzhet Inci Kilic, Kyle Matthews, Giovanni Marco Saladino, Yury Gogotsi, Per A. Larsson, Mahiar Max Hamedi   +5 more
wiley   +1 more source

Extrahepatic Gene Editing In Vivo Using Organic Solvent‐Free Lipid Nanoparticles

Small, EarlyView.
This article highlights a novel, organic solvent‐free lipid nanoparticle (LNP) formulation that avoids cholesterol, thereby reducing hepatic accumulation and immune activation. These BLNPs enable potent, flexible, and scalable gene delivery, supporting personalized medicine and diverse nucleic acid applications.
Michael Streiber, Na Liu, Laurianne Simon, Franziska Adermann, Vivien Bachmann, Lucas Gath, Stephanie Hoeppener, Stephanie Schubert, Oliver Werz, Vincent Lapinte, Marie Morille, Michael Bauer, Adrian T. Press, Ulrich S. Schubert, Anja Traeger   +14 more
wiley   +1 more source

Translational research on autotaxin-LPA-LPA receptors and drug discovery

Clinical Lipidology, 2015
The discovery that lysophosphatidic acid (LPA) acts as a signaling molecule via its G protein-coupled receptors motivated studies on the signaling and pathophysiology of LPA. Furthermore, the subsequent identification of the LPA-producing plasma phosphodiesterase, autotaxin, led to structural and mouse genetic studies of this lysophospholipase D ...
openaire   +1 more source

PFOA Exposure Elicits Quantitative Lipidomic Changes in the Pancreas in a Mouse Model of Pancreatic Cancer

Environmental Toxicology, EarlyView.
ABSTRACT Pancreatic cancer is the fourth leading cause of cancer deaths in the US and predicted to rise to second by 2030. Several risk factors have been identified as potential contributors to pancreatic cancer development including lifestyle factors and long‐term exposure to occupational and environmental carcinogens.
Barbara A. Hocevar, Lisa M. Kamendulis
wiley   +1 more source

Thriving or surviving? A latent profile analysis of resilience, psychological wellbeing and professional quality of life in early‐career veterinarians in Canada

Veterinary Record, EarlyView.
Abstract Background Various adverse mental health outcomes (e.g., burnout) have been reported and shown to impact the longevity of veterinarians’ careers, especially during the early career. Both compassion fatigue (CF) and compassion satisfaction (CS) are significant predictors of burnout.
Tipsarp Kittisiam, Caroline Ritter, Emily Morabito, Daniel Gillis, Adam Stacey, Deep Khosa, Andria Jones   +6 more
wiley   +1 more source

Detection of Leptospira in cane toads (Rhinella jimi) from urban and rural Paraíba, Brazil

Veterinary Record, EarlyView.
Abstract Background Leptospirosis is a significant zoonosis in tropical regions, where poor sanitation and favourable climate aid its spread. Synanthropic animals such as the cane toad (Rhinella jimi), which share environments with both people and wild and domestic animals, may harbour Leptospira and contribute to urban and rural transmission cycles ...
Karla N. de Souza Rocha, Aline de Lima Peixoto, Lucila S. de Medeiros Pereira, Debora Ferreira Cardoso, Maria L. C. Rodrigues Silva, Sérgio S. de Azevedo, Juliana P. F. de Oliveira, Clebert J. Alves, Mozar Alves Fonseca, Severino S. dos Santos Higino   +9 more
wiley   +1 more source

Gender‐Sensitive Resilience in Kyrgyz Households: Latent Profile and Cross‐Lagged Dynamic Panel Approaches

Australian Journal of Agricultural and Resource Economics, EarlyView.
ABSTRACT Resilience is still conceptualised as gender‐neutral in research and policy discussions. However, a gendered resilience framework suggests that gender roles and intra‐household dynamics are intricately linked with household resilience. This manuscript aims to analyse the effect of gender role attitudes on climate change resilience.
Bekhzod Egamberdiev, Lena Kuhn, Ihtiyor Bobojonov, Thomas Glauben   +3 more
wiley   +1 more source

Planning and Solar Farms: A Front Line in Net Zero Disputes?

The Political Quarterly, EarlyView.
Abstract Solar power is rapidly increasing in importance as a source of UK renewable energy. However, planning applications for solar farms have emerged as a new cleavage in what was previously a consensus policy area of acting to counter climate change.
David Toke, Costanza Concetti, Muhammad Mohsin Hussain, Paula Duffy, Jo Vergunst   +4 more
wiley   +1 more source