Results 141 to 150 of about 113,253 (324)

Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis

BMC Pulmonary Medicine, 2014
BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no effective medical therapies. Recent research has focused on identifying the biological processes essential to the development and progression of fibrosis, and on the
S. Montesi, S. Mathai, L. Brenner, I. Gorshkova, E. Berdyshev, A. Tager, B. Shea   +6 more
semanticscholar   +1 more source

Transperineal ultrasound versus digital palpation: Identifying key parameters for objective pelvic floor muscle contraction assessment

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Transperineal ultrasound demonstrates high reproducibility and objectivity in evaluating pelvic floor muscle contractility. When integrated with digital palpation, it enhances functional assessment and facilitates standardized, imaging‐based strategies for individualized pelvic floor muscle training in clinical practice.
Yun Lin, Honghong Pan, Yupeng Chen, Chenshan Dong, Yijia Luo   +4 more
wiley   +1 more source

Gender effects on the distribution of the cholesteryl ester transfer protein in apolipoprotein A-I-defined lipoprotein subpopulations.

Journal of Lipid Research, 1994
Two subpopulations of apolipoprotein A-I-containing lipoproteins, those containing only apoA-I (LpA-I) and those containing both apoA-I and apoA-II (LpA-I/A-II), were isolated by immunoaffinity chromatography of plasma from 44 subjects, comprising four ...
P Moulin, M C Cheung, C Bruce, S Zhong, T Cocke, H Richardson, A R Tall   +6 more
doaj   +1 more source

Latent Profile Analysis of Challenging Behaviour in Individuals With Intellectual Disabilities: Examining Associated Factors and Life Satisfaction

British Journal of Learning Disabilities, EarlyView.
ABSTRACT Background Challenging behaviours (CBs) are known to adversely affect life satisfaction among individuals with intellectual disabilities. Little is known about the impact of different profiles of CBs amongst individuals with intellectual disabilities in South Korea.
Yesang Cho
wiley   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Prospective association of device‐based physical activity and sedentary time during childhood with mental health outcomes during adolescence

Child and Adolescent Mental Health, EarlyView.
Background The present study aimed to analyze associations between device‐measured physical activity and sedentary time during childhood with mental health‐related outcomes throughout adolescence. Methods Data from the Millennium Cohort Study were used.
André O. Werneck, Chih‐Sung Liang, Lee Smith, Dara Aldisi, Nasser Al‐Daghri, Arnold Baca, Liye Zou, Qian Yu, Jin Kuang, Zhihao Zhang, Marco Solmi, Brendon Stubbs   +11 more
wiley   +1 more source

Lysophosphatidic Acid Triggers Apoptosis in HeLa Cells through the Upregulation of Tumor Necrosis Factor Receptor Superfamily Member 21

Mediators of Inflammation, 2017
Lysophosphatidic acid (LPA), a naturally occurring bioactive phospholipid, activates G protein-coupled receptors (GPCRs), leading to regulation of diverse cellular events including cell survival and apoptosis.
Yunzhou Dong, Yong Wu, Mei-Zhen Cui, Xuemin Xu   +3 more
doaj   +1 more source

A Transcriptomic Analysis of Cancer‐Stromal Interactome in Lung Cancer Xenograft Models

Cancer Science, EarlyView.
We conducted a comprehensive analysis of the lung cancer interactome to identify key ligand–receptor pairs involved in the aggressiveness of lung adenocarcinoma. Tumor necrosis factor superfamily member 12 and its receptor tumor necrosis factor receptor superfamily member 12A signaling axis may be potential candidates for therapeutic intervention for ...
Yuriko Takayama‐Isagawa, Daisuke Komura, Takayuki Isagawa, Yusuke Amano, Atsushi Kihara, Tamaki Miura, Taichiro Yoshimoto, Hiroyoshi Tsubochi, Kazutaka Fujita, Koichi Hagiwara, Makoto Maemondo, Tetsuo Ushiku, Shumpei Ishikawa, Noriyoshi Fukushima, Kentaro Inamura, Daisuke Matsubara, Toshiro Niki   +16 more
wiley   +1 more source

Translational research on autotaxin-LPA-LPA receptors and drug discovery

Clinical Lipidology, 2015
The discovery that lysophosphatidic acid (LPA) acts as a signaling molecule via its G protein-coupled receptors motivated studies on the signaling and pathophysiology of LPA. Furthermore, the subsequent identification of the LPA-producing plasma phosphodiesterase, autotaxin, led to structural and mouse genetic studies of this lysophospholipase D ...
openaire   +1 more source

Reallocating morning physical activity to later‐day activity and its association with type 2 diabetes incidence: The Maastricht Study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims The timing of physical activity may influence metabolic health through interactions with circadian rhythms, yet its role in type 2 diabetes mellitus (T2DM) development is unclear. We investigated associations between time‐of‐day‐specific physical activity and incident T2DM, and whether theoretically reallocating activity from morning to ...
Marvin Y. Chong, Simone J. P. M. Eussen, Jeroen H. P. M. van der Velde, Bastiaan E. de Galan, Hans H. C. M. Savelberg, Hans Bosma, Martijn J. L. Bours, Matty P. Weijenberg, Annemarie Koster   +8 more
wiley   +1 more source