Results 151 to 160 of about 88,611 (239)

Mfsd2a is important for maintaining epidermal homeostasis. [PDF]

open access: yesProc Natl Acad Sci U S A
Wong BH   +9 more
europepmc   +1 more source

Oleoylethanolamide regulates intestinal stem cell activity and villus size via PPARα signaling pathway

open access: yesiMetaOmics, Volume 3, Issue 1, March 2026.
First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang   +9 more
wiley   +1 more source

Natural History of Clinical Phenotypes and Their Biochemical Correlates in Adult X‐Linked Adrenoleukodystrophy

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT X‐linked adrenoleukodystrophy (X‐ALD) is a rare monogenic disorder characterized by marked variability in clinical presentation, age at onset, and disease progression. A deeper understanding of its natural history and the relationship between biochemical markers and clinical phenotypes is essential for improving disease monitoring, patient ...
Julia Lier   +11 more
wiley   +1 more source

Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology

open access: yesJournal of Neuroscience Research, Volume 104, Issue 3, March 2026.
Chondroitin sulfate proteoglycans (CSPGs) are critical components of the extracellular matrix in the central nervous system (CNS). In the developing CNS, CSPGs regulate neural precursor cells, neuronal migration, axon guidance, synapse organization, and peri‐neuronal net assembly.
Seyed Mojtaba Hosseini   +1 more
wiley   +1 more source

Trans‐Omics Integration Reveals That the Kidney Contributes to Systemic Aging via Sexually Dimorphic Accumulation of Glycosphingolipids

open access: yesMedComm, Volume 7, Issue 3, March 2026.
Female‐specific renal GluCer accumulation disrupts mitochondrial quality control via a conserved purine‐mTORC1 pathway, triggering a wave of uremic toxins into the systemic circulation that constitutes a female‐biased vulnerability toward renal‐driven multiorgan senescence.
Zhen Ni   +18 more
wiley   +1 more source

MLKL in liver parenchymal cells promotes liver cancer in murine metabolic dysfunction-associated steatotic liver disease. [PDF]

open access: yesCell Death Dis
Imerzoukene G   +15 more
europepmc   +1 more source

Engineering Grain Architecture in Epitaxial Aluminum on Miscut Substrates Toward Various Clean Limits and Giant Superconductivity Modulation

open access: yesSmall, Volume 22, Issue 14, 6 March 2026.
The miscut substrate strategy offers a novel means to engineer aluminum surface roughness, grain architecture, crystallinity, and both normal and superconducting transport properties toward their clean limits by precisely tuning the miscut angle without altering growth conditions.
Thi‐Hien Do   +13 more
wiley   +1 more source

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