Results 101 to 110 of about 450,617 (310)

Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]

, 2012
Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A., Fiebich, Bernd L., Aderogba, Mutalib A., Okorji, Uchechukwu P., Okorji, U. P., Fiebich, B.L., Olajide, Olumayokun A.   +6 more
core   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

LPS-TLR4 signalling is active in both WT and conditional LysMcre-gp96flox-mice.

, 2018
Peritoneal macrophages were isolated from both WT and conditional gp96-KO and treated with lipopolysaccharides (LPS) (100ng/ml) for 30, 60 and 120 minutes.
Lutz Wolfram (471467), Anne Terhalle (4857343), Michael Fried (139963), Kirstin Atrott (456032), Hassan Melhem (4857352), Jesus Cosin-Roger (4857346), Michael Scharl (139957), Gerhard Rogler (139954), Marianne R. Spalinger (450521), Claudia Stanzel (75202), Martin Hausmann (471469), Pedro A. Ruiz (4857349), Silvia Lang (450522), Isabelle Frey-Wagner (456033)   +13 more
core   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Lipopolysaccharide modifies amiloride-sensitive Na+ transport processes across human airway cells: role of mitogen-activated protein kinases ERK 1/2 and 5 [PDF]

, 2009
Bacterial lipopolysaccharides (LPS) are potent inducers of proinflammatory signaling pathways via the activation of nuclear factor-kappa B (NF-KB) and mitogenactivated protein kinase (MAPK), causing changes in the processes that control lung fluid ...
A. M. Woollhead, Házeli, M. J., Baines, DL, M. J. Hazell, Baines, D. L., Woollhead, AM, M. E. C. Dockrell, L. Gambling, Gambling, L, A. P. Albert, Dockrell, ME, D. L. Baines, Dockrell, M. E. C., Hazell, MJ, Albert, A. P., Gambling, L., Woollhead, A. M., Albert, AP   +17 more
core   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

Exploratory study of the effects of multi-site mindfulness interventions on the multifaceted self as a psychosocial indicator of mental health: A pilot study

Acta Psychologica
The multifaceted self refers to how non-clinical individuals perceive themselves as possessing a more sophisticated self-compared to others by accumulating pairs of opposing positive traits.
Philippine Chachignon, Emmanuelle Le Barbenchon, Lionel Dany, Sylvia Martin   +3 more
doaj   +1 more source

Efeitos da atividade física voluntária sobre a neuroinflamação induzida por LPS [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Desportos, Programa de Pós-Graduação em Educação Física, Florianópolis, 2015.A inflamação é uma resposta biológica que ocorre em tecidos que sofreram algum tipo de lesão ou ...
Bavaresco, Anelise
core  

LPS-induced changes in Stat3 gene expression in rat SCN.

, 2018
Adult rats were injected with LPS (1 mg/kg) either during the day at ZT6 or at night at ZT15 and were sampled 2 h, 5 h, 8 h and 24 h later (grey columns) (controls; black columns).
Zdenka Bendová (5801660), Hana Kyclerová (5801651), Jiří Novotný (5801657), Veronika Spišská (5801654), Dominika Pačesová (5801648), Simona Moravcová (431995), Barbora Melkes (4592614)   +6 more
core   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source