Amino Acid Prodrugs: An Approach to Improve the Absorption of HIV-1 Protease Inhibitor, Lopinavir
Poor systemic concentrations of lopinavir (LPV) following oral administration occur due to high cellular efflux by P-glycoprotein (P-gp) and multidrug resistance-associated proteins (MRPs) and extensive metabolism by CYP3A4 enzymes.
Mitesh Patel +4 more
doaj +1 more source
Lung-protective ventilation worsens ventilator-induced diaphragm atrophy and weakness
Background Lung–protective ventilation (LPV) has been found to minimize the risk of ventilator–induced lung injury (VILI). However, whether LPV is able to diminish ventilator–induced diaphragm dysfunction (VIDD) remains unknown.
Xian-Long Zhou +4 more
doaj +1 more source
A new solution approach to polynomial LPV system analysis and synthesis [PDF]
Based on sum-of-squares (SOS) decomposition, we propose a new solution approach for polynomial LPV system analysis and control synthesis problems.
Prajna, Stephen, Wu, Fen
core
A Comparison of LPV Gain Scheduling and Control Contraction Metrics for Nonlinear Control
Gain-scheduled control based on linear parameter-varying (LPV) models derived from local linearizations is a widespread nonlinear technique for tracking time-varying setpoints.
Manchester, Ian R. +2 more
core +1 more source
The mass-loss return from evolved stars to the Large Magellanic Cloud V. The GRAMS carbon-star model grid [PDF]
The total dust return rate from AGB and RSG star outflows is an important constraint to galactic chemical evolution models. However, this requires detailed radiative transfer (RT) modeling of individual stars, which becomes impractical for large data ...
Aringer +78 more
core +2 more sources
French guidelines on systemic treatments for moderate‐to‐severe psoriasis in adults: Update 2025
New 2025 French guidelines update psoriasis management with revised algorithms integrating recent systemic therapies. They recommend methotrexate, adalimumab or ustekinumab as first‐line treatments and provide guidance for special psoriasis forms, comorbidities, pregnancy and long‐term management.
Marie Masson Regnault +51 more
wiley +1 more source
Stent patency and outcome of TIPS through the left versus the right portal branches
Background Our purpose is to compare the stent patency and clinical outcome of trans-jugular intra-hepatic porto-systemic shunt (TIPS) through the left branch portal vein (TIPS-LPV) to the standard TIPS through the right branch (TIPS-RPV).
Mohamed S. Alwarraky +3 more
doaj +1 more source
Interval Prediction for Continuous-Time Systems with Parametric Uncertainties [PDF]
The problem of behaviour prediction for linear parameter-varying systems is considered in the interval framework. It is assumed that the system is subject to uncertain inputs and the vector of scheduling parameters is unmeasurable, but all uncertainties ...
Efimov, Denis +3 more
core +4 more sources
IFT-LPV: Data-Based Tuning of Fixed Structure Controllers for LPV Systems
Fixed structure controllers are widely used, however the tuning thereof can be cumbersome and gives no guarantee of optimality, especially when the system is Linear Parameter-Varying (LPV). Iterative Feedback Tuning (IFT) is a technique for the optimisation of a parameterised controller based on closed-loop experiments.
Navalkar, S.T. +2 more
openaire +2 more sources
Attending EPs performed ablation with shorter ILT, which likely contributed to more efficient procedures and reduced overall ablation time. ABSTRACT Introduction Pulmonary vein isolation (PVI) is a cornerstone of atrial fibrillation (AF) ablation. Unlike balloon‐based or pulsed field ablation, radiofrequency ablation requires precise catheter control ...
Hitoshi Mori +11 more
wiley +1 more source

