Results 121 to 130 of about 62,378 (164)

Molecular markers and phenotypic characterization of adult plant resistance genes Lr 34, Lr 46, Lr 67 and Lr 68 and their association with partial resistance to leaf rust in wheat

Journal of Genetics, 2019
Thirty-nine wheat genotypes were studied to estimate their partial resistance levels to leaf rust at Behira governortae during three growing seasons, i.e. 2016/2017, 2017/2018 and 2018/2019. In these genotypes, partial resistance was characterized using final leaf rust severity (FRS %) and area under disease progress curve (AUDPC).
Walid M, El-Orabey, Aladdin, Hamwieh, Shaimaa M, Ahmed   +2 more
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Red blood cell PK deficiency: An update of PK-LR gene mutation database

Blood Cells, Molecules, and Diseases, 2016
Pyruvate kinase (PK) deficiency is known as being the most common cause of chronic nonspherocytic hemolytic anemia (CNSHA). Clinical PK deficiency is transmitted as an autosomal recessive trait, that can segregate neither in homozygous or in a compound heterozygous modality, respectively.
Canu G, De Bonis M, Minucci A, Capoluongo E   +3 more
openaire   +4 more sources

Gene expression profiles in liver of zebrafish treated with microcystin-LR

Environmental Toxicology and Pharmacology, 2008
Microcystin-LR (MC-LR) is the most frequently studied cyclic heptatoxin produced by cyanobacteria, which has tremendous negative impacts on fish, while its molecular mechanism behind remained unclear at present. Here, Affymetrix Zebrafish GeneChip was used to identify alterations in gene expression of zebrafish (Danio rerio) after MC-LR exposure. Among
Lili, Wei, Baojian, Sun, Lirong, Song, Pin, Nie   +3 more
openaire   +2 more sources

Leaf Rust‐Resistance Genes Lr41, Lr42, and Lr43 Transferred from Triticum tauschii to Common Wheat

Crop Science, 1994
In order to diversify the genetic base of resistance in hard red winter wheat (Triticum aestivum L.) to leaf rust (caused by Puccinia recondita Rob. ex Desm.), five genes for resistance were transferred from the diploid goatgrass T. tauschii (Coss.) Schmal. to hexaploid wheat lines.
T. S. Cox, W. J. Raupp, B. S. Gill
openaire   +1 more source

Effects of microcystin-LR on bacterial and fungal functional genes profile in rat gut

Toxicon, 2015
The short-term exposure to microcystin-LR (MC-LR, one of the most common and toxic variants generated by toxigenic cyanobacteria) induced gut dysfunction such as generation of reactive oxygen species, cell erosion and deficient intestinal absorption of nutrients.
Juan, Lin, Jun, Chen, Jun, He, Jing, Chen, Qingyun, Yan, Jizhong, Zhou, Ping, Xie   +6 more
openaire   +2 more sources

Transcriptional responses of glutathione transferase genes in Ruditapes philippinarum exposed to microcystin-LR

2023
No abstracts are to be cited without prior reference to the author. Microcystins (MCs) are potent hepatotoxins produced by bloom-forming species of toxic cyanobacteria. Among these, MC-LR is the most commonly found and toxic variant. Bivalves, due to their benthic and sedentary mode of life, are one of the most threatened organisms by these ...
Reis, Bruno, Carneiro, Mariana, Azevedo, Joana, Vasconcelos, Vítor, Martins, José Carlos   +4 more
openaire   +1 more source

Red cell pyruvate kinase deficiency: 17 new mutations of the PK‐LR gene

British Journal of Haematology, 2005
SummaryThe PK‐LR gene was studied in 23 patients with congenital haemolytic anaemia associated with erythrocyte pyruvate kinase (PK) deficiency. Twenty‐seven different mutations were detected among the 42 mutated alleles identified: 19 missense mutations, four splice site mutations and one nonsense, one single base deletion and two large deletions ...
FERMO E, BIANCHI P, COTTON F, VERCELLATI C, WRITZL K, BAKER K, HANN I, RODWELL R, ZANELLA A., CHIARELLI, LAURENT, VALENTINI, GIOVANNA   +10 more
openaire   +3 more sources

Microcystin (-LR) induced testicular cell apoptosis via up-regulating apoptosis-related genes in vivo

Food and Chemical Toxicology, 2013
Microcystin-LR (MC-LR) can induce apoptosis of a wide range of tissue cells including testicular cells. The purpose of the study was to find out whether the expression and phosphorylation of p53, Bcl-2 protein family proteins, Cyt c, and caspases were involved in the induction of testicular cell apoptosis by MC-LR in mice. Results showed that following
Xueting, Wang, Yu, Chen, Xintong, Zuo, Naiqing, Ding, Huijuan, Zeng, Xiang, Zou, Xiaodong, Han   +6 more
openaire   +2 more sources

Molecular characterization of the PK‐LR gene in sixteen pyruvate kinase‐deficient patients

British Journal of Haematology, 2001
We studied the PK‐LR gene in 16 unrelated patients with congenital haemolytic anaemia associated with erythrocyte pyruvate kinase deficiency. Fifteen different mutations were detected among the 28 mutated alleles identified: two deletions (del 1010G, del 1042–1044); one four nucleotide duplication (nt 1515–1518, GGTC); one splice site [IVS6(−2)t]; nine
Zanella, Alberto, Bianchi, Paola, Fermo, Elisa, Iurlo, Alessandra, Zappa, Manuela, Vercellati, Cristina, Boschetti, Carla, Baronciani, Luciana, Cotton, Frédéric   +8 more
openaire   +2 more sources

CUDA-LR: CUDA-accelerated logistic regression analysis tool for gene-gene interaction for genome-wide association study

2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW), 2011
In genome-wide association studies (GWAS), logistic regression (LR) has been most commonly used for finding an association between a disease phenotype and genetic variants such as single nucleotide polymorphism (SNP). Since logistic regression model requires iterative algorithms to get the parameter estimates, its application to GWAS has been limited ...
null Sungyoung Lee, null Min-Seok Kwon, null Ik-Soo Huh, null Taesung Park   +3 more
openaire   +1 more source