Results 61 to 70 of about 1,828,400 (307)

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Identification and characteristics of wheat Lr orthologs in three rye inbred lines.

PLoS ONE, 2023
The genetic background of the immune response of rye to leaf rust (LR), although extensively studied, is still not well understood. The recent publication of the genome of rye line Lo7 and the development of efficient transcriptomic methods has aided the
Tomasz Krępski, Mateusz Olechowski, Izabela Samborska-Skutnik, Magdalena Święcicka, Agnieszka Grądzielewska, Monika Rakoczy-Trojanowska   +5 more
doaj   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Identification of Leaf Rust-Related Gene Signature in Wheat (Triticum Aestivum L.) Using High-Throughput Sequencing, Network Analysis, and Machine Learning Algorithms

Rice
Wheat provides staple food and industrial raw material for humans and animals, but its production decreased due to leaf rust (Lr) disease caused by Puccinia triticina by up to 15%.
Muhammad Farhan, Muhammad Ikram, Jing-E Sun, San-Wei Yang, Yong Wang   +4 more
doaj   +1 more source

Resistance of spring wheat Triticum aestivum L. to leaf rust under the conditions of the Central Non-Black-Earth region

RUDN Journal of Agronomy and Animal Industries
The results of experimental studies on field resistance of spring common wheat ( Triticum aestivum L . ) varieties to leaf rust in the Central Region of the Non-Black Soil Zone of Russia were described. Fifteen spring wheat varieties were evaluated under
Boburjon B. Najodov, Valentina S. Rubets, Mikhail G. Divashuk   +2 more
doaj   +1 more source

Genome‐Wide Association Study of a Worldwide Collection of Wheat Genotypes Reveals Novel Quantitative Trait Loci for Leaf Rust Resistance

The Plant Genome, 2019
Core Ideas The emergence of new virulent Puccinia triticina races requires a continuous search for novel sources of resistance to combat leaf rust (LR) disease Twenty‐two wheat genotypes resistant to four P.
Suraj Sapkota, Yuanfeng Hao, Jerry Johnson, James Buck, Meriem Aoun, Mohamed Mergoum   +5 more
doaj   +1 more source

Extending Service Beyond Active Duty: Generalizability of Rheumatoid Arthritis Research Conducted Among U.S. Veterans

Arthritis Care &Research, Accepted Article.
Biomedical research involving United States Veterans continues to advance healthcare beyond the Veterans Health Administration. This is particularly true in rheumatoid arthritis (RA), where Veteran‐centric research has uncovered novel insights into pathogenesis, risk factors, and disease manifestations, informing clinical care and research across both ...
Austin M. Wheeler, Joshua F. Baker, Jennifer L. Barton, Maria I. Danila, Tate M. Johnson, Kamini Kuchinad, Kaleb Michaud, Amir A. Razmjou, J. Steuart Richards, Namrata Singh, Isaac D. Smith, Katherine D. Wysham, Grant W. Cannon, Bryant R. England, Amy Joseph, Deana Lazaro, Katherine P. Liao, Courtney Loecker, Andreas Reimold, Beth I. Wallace, Ted R. Mikuls   +20 more
wiley   +1 more source

Chronic Microcystin-LR Exposure Induces Abnormal Lipid Metabolism via Endoplasmic Reticulum Stress in Male Zebrafish

Toxins, 2020
In order to explore effects of low levels of continuous microcystin-LR (MC-LR) (a cyanotoxin) exposure on hepatic lipid metabolism on the basis of the endoplasmic reticulum stress (ERS) pathway, we exposed adult male zebrafish to MC-LR (0, 1, 5, and 25 &#
Dandan Zhang, Wang Lin, Yinjie Liu, Honghui Guo, Lingkai Wang, Liping Yang, Li Li, Dapeng Li, Rong Tang   +8 more
doaj   +1 more source

Dietary exposure of the water flea Daphnia galeata to microcystin-LR

Harmful substances like the cyanotoxin microcystin-leucine-arginine (MC-LR) are commonly found in eutrophic freshwater environments, posing risks to aquatic organisms.
Yeon-jeong Park (17870330), Seong-il Eyun (549328), Eun-jeong Kim (17870327), Hyunmin Woo (17870333), Donggu Jeon (13790443)   +4 more
core   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source