Results 51 to 60 of about 18,853 (204)

Integrating Scale Out and Fault Tolerance in Stream Processing using Operator State Management [PDF]

, 2013
As users of big data applications expect fresh results, we witness a new breed of stream processing systems (SPS) that are designed to scale to large numbers of cloud-hosted machines.
Fernandez, RC, Kalyvianaki, E, Migliavacca, M, Pietzuch, P   +3 more
core   +1 more source

Analytical Approaches to Address Challenges in the Analysis of Cannabinoids in Vascular Matrices Using Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Phytocannabinoids are bioactive metabolites derived from the Cannabis sativa plant. They have garnered attention due to their recreational uses and therapeutic potential. Although various analytical strategies have been employed for their analysis, mass spectrometry (MS) coupled to chromatographic separation is superior due to its sensitivity ...
Radwa Mahmoud, Robert B. Laprairie, Anas El‐Aneed   +2 more
wiley   +1 more source

Pharmacokinetics and Safety of Lurbinectedin Administrated with Itraconazole in Cancer Patients: A Drug–Drug Interaction Study

Marine Drugs
This open-label, two-part, phase Ib drug–drug interaction study investigated whether the pharmacokinetic (PK) and safety profiles of lurbinectedin (LRB), a marine-derived drug, are affected by co-administration of itraconazole (ITZ), a strong CYP3A4 ...
Irene Moreno, Tatiana Hernández, Emiliano Calvo, Salvador Fudio, Carmen Kahatt, Sara Martínez, Jorge Luis Iglesias, Román Octavio Calafati, Laura Pérez-Ramos, Lola Montilla, Ali Zeaiter, Rubin Lubomirov   +11 more
doaj   +1 more source

Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo

Neurobiology of Disease, 2006
RNA interference (RNAi) has the potential to treat diseases caused by dominant, gain-of-function type of gene mutations. In these diseases, one allele is mutated and produces a toxic protein, whereas the other allele is normal and performs vital ...
Xugang Xia, Hongxia Zhou, Yong Huang, Zuoshang Xu   +3 more
doaj   +1 more source

The Great Observatories Origins Deep Survey - VLT/VIMOS Spectroscopy in the GOODS-South Field: Part II

, 2010
We present the full data set of the VIMOS spectroscopic campaign of the ESO/GOODS program in the CDFS, which complements the FORS2 ESO/GOODS spectroscopic campaign.
A. Rettura, Ando, Bruzual, Bunker, C. Cesarsky, Cimatti, Cohen, Cristiani, Croom, Daddi, Dickinson, E. Vanzella, Giacconi, Giavalisco, Gilli, Grazian, H. Kuntschner, H. Teimoorinia, I. Balestra, Kang, Le Fèvre, Lehmer, Luo, M. Dickinson, M. Nonino, Mignoli, Nonino, P. Popesso, P. Rosati, Pentericci, Pentericci, Popesso, R. A.E. Fosbury, Ravikumar, S. Cristiani, Scodeggio, Shapley, Stanway, Strolger, Szokoly, Tapken, V. Mainieri, van der Wel, Vanzella, Vanzella, Vanzella, Vanzella, Verhamme   +47 more
core   +1 more source

LRB-based hybrid base isolation systems for cable-stayed bridges [PDF]

Journal of the Earthquake Engineering Society of Korea, 2004
This paper presents LRB-based hybrid base isolation systems employing additional active/semiactive control devices for mitigating earthquake-induced vibration of a cable-stayed 29 bridge. Hybrid base isolation systems could improve the control performance compared with the passive type-base isolation system such as LRB-installed bridge system due to ...
openaire   +1 more source

Burrow Persistence and Spatial Distribution of Federally and State‐Protected Gopher Tortoise (Gopherus polyphemus) Populations in Southwest Alabama

Animal Conservation, EarlyView.
The gopher tortoise (Gopherus polyphemus), a keystone species and ecosystem engineer, has declined by ~80% over the past century due to primarily habitat loss. In a 28‐year resurvey of federally protected Mobile County and state‐protected Baldwin County, we found tortoise populations persisted at ~59% and ~31% of sites, respectively, with significant ...
Robin B. Lloyd Jr., Jeremiah A. Henning, Steven R. Schultze, David H. Nelson, Adam D. Chupp   +4 more
wiley   +1 more source

A single-domain antibody for the detection of pathological Tau protein in the early stages of oligomerization

Journal of Translational Medicine
Background Soluble oligomeric forms of Tau protein have emerged as crucial players in the propagation of Tau pathology in Alzheimer’s disease (AD). Our objective is to introduce a single-domain antibody (sdAb) named 2C5 as a novel radiotracer for the ...
Nicolas De Leiris, Pascale Perret, Charlotte Lombardi, Bülent Gözel, Sabine Chierici, Philippe Millet, Marlène Debiossat, Sandrine Bacot, Benjamin B. Tournier, Patrick Chames, Jean-Luc Lenormand, Catherine Ghezzi, Daniel Fagret, Marcelle Moulin   +13 more
doaj   +1 more source

Abundance of Collembola in Biopore Infiltration Holes Filled with Organic Waste and Animal Waste

Florea: Jurnal Biologi dan Pembelajarannya
Garbage and flooding are environmental problems that need attention. One solution to dealing with organic waste and flooding is the creation of biopore absorption holes (LRB). Organic waste can be processed into compost with the help of soil animals such
Leo Eladisa Ganjari, Christianto Adhy Nugroho   +1 more
doaj   +1 more source

Characterization of a stress tolerance‐defective mutant of Lactobacillus rhamnosus LRB

Molecular Oral Microbiology, 2019
Abstract Lactobacillus rhamnosus is a lactic acid bacterium that survives diverse ecological niches, including the human oral cavity and gastrointestinal tract. L. rhamnosus is an acidogenic bacterium that produces copious amounts of lactic acid.
Saswati Biswas, Andrew Keightley, Indranil Biswas   +2 more
openaire   +3 more sources