Results 161 to 170 of about 4,566 (176)
LRP1B Functions as a Receptor for Pseudomonas Exotoxin
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2005 Pseudomonas aeruginosa is an opportunistic pathogen that produces several virulence factors, among them Pseudomonas Exotoxin A (PE). Previously, low-density lipoprotein receptor-related protein 1 (LRP1) was shown to be the primary receptor for PE.
Guojun Bu, David J Fitzgerald
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Down-Regulation of LRP1B in Colon Cancer Promoted the Growth and Migration of Cancer Cells
Experimental Cell Research, 2017Aberrant activation of beta-catenin/TCF signaling is one of the hallmarks of colon cancer. It is of great interest to study the mechanism for the regulation of beta-catenin/TCF signaling. In this study, it was found that LRP1B was down-regulated in colon cancer tissues and inhibited the growth, migration and metastasis of colon cancer cells.
Chun Gao, Ming Xu, Ji Chen
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Immune checkpoint inhibitor response in tumors with LRP1B variants.
Journal of Clinical Oncology, 2019e14291 Background: Low-density lipoprotein receptor-related protein 1B (LRP1B) is a putative tumor suppressor gene spanning > 500 kb on chromosome 2. A melanoma study previously reported enrichment of LRP1B mutations in responders (34%) to immune checkpoint inhibitors (ICIs) compared with non-responders (3%). Deep deletions in LRP1B are frequently
Jason Zhu +16 more
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LRP1B Attenuates the Migration of Smooth Muscle Cells by Reducing Membrane Localization of Urokinase and PDGF Receptors [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2004 Objective— Studies on the involvement of low-density lipoprotein receptor relatives (LRs) in atherosclerosis have recently gained new focus because of the specific expression of certain of these receptors in the thickened intima.
Tatsuro Kanaki +2 more
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[Silencing LRP1B with huge transcript by RNAi method].
Yi chuan = Hereditas, 2009Lipoprotein receptor-related protein 1 B (LRP1B) is one of gigatic receptor subgroup members of lipoprotein receptor family. LRP1B encodes a huge transcript of 16.5 kb. There were difficulties for analysis of LRP1B function due to its huge transcript.
Ruo, Li +5 more
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LRP1B in cancer: From a mutation landscape to predictive biomarkers for precision oncology
Mutation Research - Reviews in Mutation ResearchLow-density lipoprotein receptor-related protein 1B (LRP1B) is one of the most frequently mutated genes across a wide range of malignancies and has garnered increasing attention owing to its crucial role in tumorigenesis and clinical outcomes. Emerging evidence suggests that LRP1B mutations not only disrupt essential cellular processes such as ...
Likun, Yang +3 more
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Antitumor Immunity and Prognosis Value Elicited by FAT3 and LRP1B Co-Mutation in Endometrial Cancer
Gynecologic OncologyFAT3 and LRP1B are two tumor suppressor genes with high mutation frequency in multiple cancer types, we sought to investigate the prognostic and immunological significance of these two genes in EC.Based on a cohort of 502 EC samples, we conducted a comprehensive analysis of its multidimensional data types including genomic, transcriptomic, and clinical
Yanfang Yang +2 more
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A genome screen of successful aging without cognitive decline identifies LRP1B by haplotype analysis
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2009AbstractSuccessful aging without cognitive decline (SA) is apparent in those who escape age‐related illnesses, such as cardiovascular disease and dementia. To determine whether there are protective genotypes that increase the probability of successful cognitive aging, a genome‐wide screen was conducted on subjects who were 85 years of older, had MMSE ...
S E, Poduslo, R, Huang, A, Spiro
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Relationship of liver cancer with LRP1B or TP53 mutation and tumor mutation burden and survival.
Journal of Clinical Oncology, 20191573 Background: Liver cancer (LC), one of the most common causes of cancer-related deaths, is a serious medical problem due to the limited treatment options available for this disease. Immune checkpoint inhibitors (ICIs) that are proved to be beneficial in the treatment of advanced LC.
Longrong Wang +10 more
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Investigating the role of LRP1B in chemo-resistance in advanced triple-negative breast cancer.
Journal of Clinical Oncologye13150 Background: Advanced triple-negative breast cancer is usually chemo-resistant with high mortality. We aimed to develop novel therapeutic strategies to overcome chemo-resistance in triple-negative breast cancer.
Qixiang Rong, Haifeng Li, Yanxia Shi
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