Results 131 to 140 of about 19,899 (238)
Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.Abstract INTRODUCTION Limbic‐predominant age‐related transactive response DNA binding protein 43 kDa encephalopathy neuropathological change (LATE‐NC) frequently co‐occurs with Alzheimer's disease neuropathologic change (ADNC), complicating classification.
Qi Qiao +9 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.Abstract INTRODUCTION Epigenome‐wide association studies implicate DNA methylation in Alzheimer's disease (AD) pathology. Although recent studies identified epigenetic signatures within non‐neuronal cell types in disease risk, the role of the methylome in glial cell types (i.e., astrocytes, oligodendrocytes) in biological aging and AD pathogenesis is ...
Uchit Bhaskar +2 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai +9 more
wiley +1 more source
The regulation of stem cell fate and its application in neural regeneration
Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He +3 more
wiley +1 more source
Pathological Functions of LRRK2 in Parkinson’s Disease
, 2020 Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are common genetic risk factors for both familial and sporadic Parkinson’s disease (PD).
Byoung Dae Lee, Ga Ram Jeong
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Journal of the Chinese Chemical Society, Volume 73, Issue 9, Page 1218-1229, September 2026.Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley +1 more source
N-term-LRRK2 is more insoluble than WT-LRRK2 in SH-SY5Y cells.
, 2012 SH-SY5Y cells were transfected with EGFP-LRRK2 (WT, N-term, C-term) or HA-LRRK2 (WT, N-term) constructs and harvested 16 h later. Cells were lysed and fractionated as described in the Methods followed by western blot analysis.
Mark T. Fahey (136219) +3 more
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Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 9, September 2026.Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li +3 more
wiley +1 more source
Movement Disorders Clinical Practice, Volume 13, Issue 9, Page 2216-2224, September 2026.Abstract Background LRRK2‐Parkinson's disease (LRRK2‐PD) is biologically heterogeneous with approximately 30% lacking aggregated alpha synuclein (αSyn) in cerebrospinal fluid by seed amplification assay (SAA). Prior work has suggested slower progression in LRRK2‐PD compared to sporadic PD (sPD).
Lucy A. Morse +224 more
wiley +1 more source
The Global Parkinson's Disease Genetics (GP2) Genome Browser
Movement Disorders, Volume 41, Issue 9, Page 2512-2517, September 2026.Abstract Background Large‐scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson's disease (PD) risk and disease‐causing variants, we developed an open‐access, summary‐level genomic data browser.
Zih‐Hua Fang +15 more
wiley +1 more source