Results 141 to 150 of about 28,054 (245)
Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise +4 more
wiley +1 more source
Inflammation and IL-4 regulate Parkinson’s and Crohn’s disease associated kinase LRRK2
EMBO ReportsMutations in Leucine-Rich Repeat protein Kinase 2 (LRRK2) are associated with Parkinson’s disease (PD) and Crohn’s disease (CD), but the regulation of LRRK2 during inflammation remains relatively unexplored.
Dina Dikovskaya +9 more
doaj +1 more source
Progress of Immunotherapies in Parkinson's Disease
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.Parkinson's disease (PD) is caused by an immune disorder triggered by α‐synuclein, leading to a persistent neuroinflammatory cycle that drives the disease from non‐motor symptoms to the motor stage. Second, it presents active and passive immunotherapy strategies targeting α‐synuclein and their potential in slowing down the disease progression.
Yong Peng +10 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.Oxidative stress induced by MPTP promotes hnRNP A1/A2–dependent alternative splicing toward PKM2 in dopaminergic neurons. Elevated PKM2 transactivates Nrf2, enhances antioxidant gene expression, and protects neurons from oxidative damage and degeneration.
Meng Mei +6 more
wiley +1 more source
Organoids: From Bench to Bedside Applications
MedComm, Volume 7, Issue 6, June 2026.Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li +6 more
wiley +1 more source
MedComm, Volume 7, Issue 6, June 2026.This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang +8 more
wiley +1 more source
Cilia in Nervous System Development, Function, and Disease
MedComm – Future Medicine, Volume 5, Issue 2, June 2026.Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley +1 more source
Phytotherapy Research, Volume 40, Issue 6, Page 3354-3368, June 2026.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo +3 more
wiley +1 more source
Clinical Breakthrough in Targeted Protein Degradation: Reflections on the Approval of ARV‐471
Cancer Innovation, Volume 5, Issue 3, June 2026.
Yu Rao
wiley +1 more source
Pleiotropic effects of variants in dementia genes in Parkinson disease [PDF]
, 2018 Benitez, Bruno A +11 more
core +2 more sources