Results 141 to 150 of about 19,899 (238)

Rare‐Variant Burden across Lysosomal Genes Implicates Sialylation and Ganglioside Metabolism in Parkinson's Disease

Movement Disorders, Volume 41, Issue 9, Page 2349-2356, September 2026.
Abstract Background Lysosomal dysfunction is central to Parkinson's disease (PD) pathogenesis, with GBA1 representing the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid, and ceramide metabolism have been proposed as contributors to PD, highlighting the need for genetic analyses ...
Konstantin Senkevich, Sitki Cem Parlar, Cloe Chantereault, Lang Liu, Eric Yu, Uladzislau Rudakou, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Lior Greenbaum, Sharon Hassin‐Baer, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Roy N. Alcalay, Ziv Gan‐Or   +21 more
wiley   +1 more source

LRRK2 interacts with p62.

, 2016
A. HEK 293T cells were transiently co-transfected with FLAG-tagged p62 (FLAG-p62), c-myc-tagged LRRK2 (myc-LRRK2), or both. Twenty-four hours after transfection, total cell lysates were subjected to immunoprecipitation with anti-c-myc monoclonal antibody
Seulki Han (3121518), Young Ho Suh (354184), Eun-Hye Joe (1940146), Beomsue Kim (172914), Sangwook Park (379863), Seung Pyo Park (811698), Insup Choi (3121521)   +6 more
core   +1 more source

Inflammation and IL-4 regulate Parkinson’s and Crohn’s disease associated kinase LRRK2

EMBO Reports
Mutations in Leucine-Rich Repeat protein Kinase 2 (LRRK2) are associated with Parkinson’s disease (PD) and Crohn’s disease (CD), but the regulation of LRRK2 during inflammation remains relatively unexplored.
Dina Dikovskaya, Rebecca Pemberton, Matthew Taylor, Anna Tasegian, Purbasha Bhattacharya, Karolina Zeneviciute, Esther M Sammler, Andrew J M Howden, Dario R Alessi, Mahima Swamy   +9 more
doaj   +1 more source

Imaging patterns and genetic associations of brain atrophy across distinct symptom stages in Parkinson's disease

Neuroprotection, Volume 4, Issue 3, Page 262-274, September 2026.
Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji, Liujia Lu, Kaidong Chen, Ruixuan Zhang, Yao Lu, Yachen Shi, Xiangming Fang   +6 more
wiley   +1 more source

Analysis of LRRK2 levels.

, 2018
(A) Strategy to insert an SF-TAP tag at the N-terminus of exon 1 of LRRK2. A TALEN pair targeting exon 1 of LRRK2 was administered along with a donor construct containing homology arms flanking the SF-TAP tag (green box) and a neomycin resistance ...
Andrea Meixner (4919071), Julia Catherine Fitzgerald (4919068), David Schöndorf (4919080), Lydia Reinhardt (4919074), Michael Glatza (393601), Michela Deleidi (219439), Thomas Gasser (33499), Christine Bus (4919077), Manuela Kübler (4919065), Peter Reinhardt (327591), Christian Johannes Gloeckner (238484), Lara Marrone (4919086), Tanya Levin (4919083), Benjamin Schmid (125863), Barbara Klink (391506), Jared Sterneckert (393607)   +15 more
core   +1 more source

Rethinking Senescence Hallmarks in the Brain: Lessons From Peripheral Tissues and Challenges in Defining Neuronal Senescence

Aging Cell, Volume 25, Issue 9, September 2026.
Neuronal senescence‐like states arise from convergent intrinsic and disease‐associated stressors and are linked to persistent dysfunction, SASP‐like signaling, and altered glial interactions. Because no single marker is definitive in post‐mitotic neurons, multimarker and context‐dependent frameworks are required to define their role in ...
Miraj Ud Din Momand, Kristina Macova, Dominika Fricova   +2 more
wiley   +1 more source

ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?

, 2013
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. LRRK2 kinase activity is required for toxicity in neuronal cell cultures suggesting that selective kinase inhibitors may prevent ...
Gillardon, F., Kremmer, E., Hengerer, B., Gloeckner, C.J., Froehlich, T., Ueffing, M.   +5 more
core   +1 more source

LRRK2 and RAB8A regulate cell death after lysosomal damage in macrophages through cholesterol-related pathways

Neurobiology of Disease
Activating mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are among the most common genetic causes of Parkinson's disease (PD). The mechanistic path from LRRK2 mutations to PD is not established, but several lines of data suggest that LRRK2 modulation
Josefine Fussing Tengberg, Francesco Russo, Tau Benned-Jensen, Jacob Nielsen   +3 more
doaj   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, Volume 36, Issue 5, September 2026.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

From Pits to Plaques: Electron Microscopy Reveals Clathrin Structural Plasticity in Trafficking, Sorting and Adhesion

Traffic, Volume 27, Issue 3, September 2026.
Clathrin plaques (magenta) form large, flat membrane‐associated lattices embedded within the cortical actin cytoskeleton, and can be distinguished from individual clathrin‐coated pits (yellow). These structures are surrounded by a dense network of actin filaments and associated proteins, illustrating the intimate structural coupling between clathrin ...
Marion Benoist, Stéphane Vassilopoulos
wiley   +1 more source