Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and glucocerebrosidase activity. [PDF]
ElifeMeneses-Salas E +11 more
europepmc +1 more source
Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies [PDF]
, 2018 et al.,, Karch, Celeste M, Wen, Natalie
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cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis. [PDF]
Cell Death DisZhang Y, Zhu Z, Ji P, Ming J, Zhou Y.
europepmc +1 more source
Axonal Transport Deficits in Parkinson's Disease: Insights from Neurotoxin, Genetic, and Sporadic Models. [PDF]
Brain SciWang X, Liu Z, Smith WW.
europepmc +1 more source
Convergent transcriptomic signature in iPSC-dopaminergic neurons of hereditary Parkinson's disease. [PDF]
Life Sci AllianceKopylova IV +11 more
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Intestinal inflammation promotes neuroinflammation and PD-associated nigrostriatal pathology independently of LRRK2 G2019S kinase activity. [PDF]
Front Cell NeurosciMerchak AR +5 more
europepmc +1 more source
Discovery of Novel Chemotype LRRK2 Inhibitors Through AlphaFold2-Generated Structure-Based Docking Screen. [PDF]
Int J Mol SciBaral R, Lee JI, Jee JG.
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LRRK2 I1371V Mutation Drives Astrocytic Glucose Metabolism Failure and Induces Integrated ER-Mitochondria-Lysosome Dysfunction in Parkinson's Disease. [PDF]
Int J Mol SciBanerjee R +6 more
europepmc +1 more source