Results 161 to 170 of about 19,899 (238)

The LRRK2 G2019S variant rewires Rab GTPase phosphorylation after lysosomal damage and promotes cell death in human macrophages. [PDF]

J Cell Sci
Morrison R, Mihaylov SR, Luk CH, Lemerle C, Rodgers A, Athanasiadi N, Morris HR, Pellegrino E, Ultanir SK, Gutierrez MG.   +9 more
europepmc   +1 more source

LRRK2 Mutation Alters Dopamine D2 Receptor Localization in Induced Pluripotent Stem Cells-Derived Astrocytes From Parkinson's Disease Patients: Implications for Neuronal Damage. [PDF]

J Neurochem
Mutti V, Bono F, Tomasoni Z, Fadel D, Gnutti C, Sbrini G, Gaudenzi C, Salvi V, Bosisio D, Russo I, Bolognin S, Schwamborn JC, Missale C, Fiorentini C.   +13 more
europepmc   +1 more source

LRRK2 Gene [PDF]

, 2020
openaire   +1 more source

Lasker~Bloomberg Public Service Award to Michael J. Fox: The challenge of Parkinson's disease. [PDF]

Proc Natl Acad Sci U S A
Schekman R.
europepmc   +1 more source

Selective loss of primary cilia and neurotrophic signaling in G51D α-synuclein mice highlights a common pathway to Parkinson's disease. [PDF]

Proc Natl Acad Sci U S A
Lin YE, Jaimon E, Kim Y, Loftman A, Vijayakumaran A, Belfort BDW, Chiang CY, Arenkiel BR, Zoghbi HY, Pfeffer SR.   +9 more
europepmc   +1 more source

Vacuolar protein sorting 35 regulates retinal neurovascular function <i>via</i> astrocyte-mediated inflammatory response in a diabetic mouse model. [PDF]

Int J Ophthalmol
Li C, Sun YR, Hu QM, Luo LL, Chen X, Zhou SH, Xu J, Li X, Liu W.   +8 more
europepmc   +1 more source

An LRRK2 variant blocks NCOA4 trafficking upon iron overload, leading to ferroptotic death. [PDF]

J Cell Sci
Goldman A, Nguyen M, Lanoix J, Li C, Fahmy A, Xu YZ, Schurr E, Thibault P, Desjardins M, McBride HM.   +9 more
europepmc   +1 more source

Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons. [PDF]

Nat Commun
Chen C, He Q, Tombesi G, Napier E, Jaconelli M, Moreno-Ramos OA, Serio H, Naaldijk Y, Promes V, Schneeweis A, Quinn K, Nasios C, Greggio E, Kozorovitskiy Y, Arango D, Khan AR, Alessi DR, Dombeck DA, Hilfiker S, Awatramani R, Parisiadou L.   +20 more
europepmc   +1 more source

Leucine-rich repeat kinase 2 (LRRK2): balancing cellular homeostasis and Parkinson's disease (PD) pathogenesis. [PDF]

Ann Med
Aolymat I, Abu-Hassan DW, Oleimat AK, Sameer W, Wreikat B, Iqilan T, Al-Momani H, Ali H, Tahtamouni L, Iqsairi M, Albeik M, Debas O.   +11 more
europepmc   +1 more source

VPS35 mutation inhibits PINK1/parkin-mediated mitophagy via increased LRRK2 kinase activity. [PDF]

Brain
Manders L, Heyninck T, Imberechts D, Holst B, Krüger R, Vandenberghe W.   +5 more
europepmc   +1 more source