Results 151 to 160 of about 19,899 (238)

Addressing the Challenges of Translating LRRK2 Biology into Disease‐Modifying Therapies: The LRRK2 Investigative Therapeutics Exchange Initiative

Movement Disorders, Volume 41, Issue 9, Page 2280-2288, September 2026.
Esther Sammler, Francesca Tonelli, Michelle Durborow, Jim McNasby, Todd Sherer, Mahmood Ahmed, Stevan W. Djuric, Kalpana Merchant, Alastair Reith, Darryle Schoepp, Christine Klein, Shalini Padmanabhan, Dario R. Alessi   +12 more
wiley   +1 more source

LRRK2: Molecular Mechanisms in Parkinson's Disease. [PDF]

Int J Mol Sci
Arias-Carrión O, Guerra-Crespo M, Ortuño-Sahagún D, Ortega-Robles E.   +3 more
europepmc   +1 more source

Protocol to quantify LRRK2-mediated Rab10 phosphorylation using high-content imaging. [PDF]

STAR Protoc
Masotti B, Lorenzon P, Covello G, Greggio E.   +3 more
europepmc   +1 more source

Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress. [PDF]

iScience
Sakurai M, Kuwahara T, Suenaga S, Takatori S, Tomita T, Shalit T, Tengstrand E, Hsieh F, Iwatsubo T.   +8 more
europepmc   +1 more source

Exploring cerebral small vessel disease signatures in familial Parkinson's disease. [PDF]

Sci Rep
Mahat B, Malla B, Foddis M, Beule D, Bras J, Guerreiro R, Kola V, Schmitt HM, Endres M, Sassi C.   +9 more
europepmc   +1 more source

LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics. [PDF]

Elife
Tombesi G, Kompella S, Favetta G, Chen C, Ornaghi M, Zhao Y, Morosin E, Sevegnani M, Lama A, Marte A, Battisti I, Iannotta L, Plotegher N, Civiero L, Onofri F, Eickholt BJ, Piccoli G, Arrigoni G, Beccano-Kelly D, Manzoni C, Parisiadou L, Greggio E.   +21 more
europepmc   +1 more source

Recent medicinal chemistry efforts of targeting protein kinases for treating neurological conditions of Parkinson's and Alzheimer's diseases. [PDF]

RSC Adv
Kaur R, Lang DK, Sood A, Singh TG, Chandrasekaran B, Al-Sha'er MA.   +5 more
europepmc   +1 more source

Correction: Quintero-Espinosa et al. LRRK2 Knockout Confers Resistance in HEK-293 Cells to Rotenone-Induced Oxidative Stress, Mitochondrial Damage, and Apoptosis. <i>Int. J. Mol. Sci.</i> 2023, <i>24</i>, 10474. [PDF]

Int J Mol Sci
Quintero-Espinosa DA, Sanchez-Hernandez S, Velez-Pardo C, Martin F, Jimenez-Del-Rio M.   +4 more
europepmc   +1 more source

In-cell cryo-electron tomography reveals differential effects of type I and type II kinase inhibitors on LRRK2 filament formation and microtubule association. [PDF]

Elife
Basiashvili T, Hutchings J, Chen S, Karasmanis EP, Flaherty WA, Leschziner AE, Villa E.   +6 more
europepmc   +1 more source

LRRK2 G2019S reprograms innate and adaptive immunity to drive context-dependent host defense outcomes. [PDF]

Front Cell Neurosci
Merchak AR, Herrick MK, Houser MC, Moustafa DA, Goldberg JB, Boss JM, Kohlmeier J, Cook DM, Keating CE, Chang J, West AB, Tansey MG.   +11 more
europepmc   +1 more source