Results 151 to 160 of about 28,054 (245)

Leucine-rich repeat kinase 2 (LRRK2): balancing cellular homeostasis and Parkinson's disease (PD) pathogenesis. [PDF]

Ann Med
Aolymat I, Abu-Hassan DW, Oleimat AK, Sameer W, Wreikat B, Iqilan T, Al-Momani H, Ali H, Tahtamouni L, Iqsairi M, Albeik M, Debas O.   +11 more
europepmc   +1 more source

Strategies for Optimizing Genetic Mouse Models to Enhance the Understanding of Parkinson's Disease. [PDF]

Biomedicines
Shen Z, Ma L, Mellick GD.
europepmc   +1 more source

Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation. [PDF]

Cell Rep
Fricke M, Mechel A, Evers L, Twellsieck B, Grein JM, Cima-Omori MS, Al-Azzani M, Outeiro TF, Zweckstetter M, Holzbaur ELF, Boecker CA.   +10 more
europepmc   +1 more source

Leucine-Rich Repeat Kinase 2 (LRRK2) in Glucose Metabolism and Metabolic-Neuroinflammatory Crosstalk. [PDF]

Biomolecules
Kawakami F, Imai M, Ogata M, Habata T, Tamaki S, Kawashima R, Kurosaki Y, Miyai S, Chatatikun M, Kyaw MP, Ohba K.   +10 more
europepmc   +1 more source

LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal integrity via phosphorylation within its lipid-sensing ALPS2 motif. [PDF]

Front Mol Neurosci
Islam MS, Cóppola-Segovia V, Musso A, Moore DJ.   +3 more
europepmc   +1 more source

Synergistic Effects of Multi-Kinase Inhibition on <i>LRRK2</i>-G2019S and Alpha-Synuclein Pathologies in Models of Parkinson's Disease. [PDF]

Biomedicines
Liu X, Baxely S, Hebron ML, Moussa C.
europepmc   +1 more source

The emerging role and therapeutic targeting of autophagy-lysosome pathway in the pathogenesis of Parkinson's disease. [PDF]

Transl Neurodegener
Shimizu T, Isik S, Kamath N, Yue Z.
europepmc   +1 more source

miR-369-3p Modulates LRRK2-Mediated Inflammation and Autophagy in RAW264.7 Macrophages. [PDF]

Int J Mol Sci
Scalavino V, Piccinno E, Grassi I, Armentano R, Giannelli G, Serino G.   +5 more
europepmc   +1 more source

Structural and biochemical basis of ROC-dependent activation of LRRK2. [PDF]

PNAS Nexus
Park Y, Wu C, Tennessen K, Wan L, Hoang NC, Hoang CW, Liao J, Hoang QQ.   +7 more
europepmc   +1 more source

Parkinson's Disease: The Catabolic Theory [PDF]

, 2013
Manzoni, C
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