Results 181 to 190 of about 19,899 (238)

Preformed fibrils of α-synuclein rapidly activate LRRK2 on early endosomes, driving Rab5 phosphorylation and disrupting endolysosomal and synaptic function. [PDF]

NPJ Parkinsons Dis
Zuo X, Chen Z, Chen XQ, Guan D, Shaw PX, Johnstone A, Becker A, Das U, Mobley WC.   +8 more
europepmc   +1 more source

The LRRK2 G2385R Exonic Variant and Multiple System Atrophy: Findings from the Japan MSA Registry. [PDF]

Mov Disord
Orimo K, Mitsui J, Tsuji S.
europepmc   +1 more source

Strategies for Optimizing Genetic Mouse Models to Enhance the Understanding of Parkinson's Disease. [PDF]

Biomedicines
Shen Z, Ma L, Mellick GD.
europepmc   +1 more source

Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation. [PDF]

Cell Rep
Fricke M, Mechel A, Evers L, Twellsieck B, Grein JM, Cima-Omori MS, Al-Azzani M, Outeiro TF, Zweckstetter M, Holzbaur ELF, Boecker CA.   +10 more
europepmc   +1 more source

Leucine-Rich Repeat Kinase 2 (LRRK2) in Glucose Metabolism and Metabolic-Neuroinflammatory Crosstalk. [PDF]

Biomolecules
Kawakami F, Imai M, Ogata M, Habata T, Tamaki S, Kawashima R, Kurosaki Y, Miyai S, Chatatikun M, Kyaw MP, Ohba K.   +10 more
europepmc   +1 more source

Retromer-targeted therapy for neurodegenerative diseases. [PDF]

Mol Neurodegener
Persico M, Tuithung S, Lorenzo A, Crawford D, Eleuteri S, Simon DK.   +5 more
europepmc   +1 more source

Novel Exploratory Transcriptomic Candidates as Biomarkers and Cancer Hallmark Fingerprints for Ovarian Endometroid and Clear Cell Carcinomas in Women. [PDF]

Antioxidants (Basel)
Kordowitzki P, Ying K.
europepmc   +1 more source

Ex Vivo LRRK2 Activation in Asian G2385R and R1628P Variant Carriers and Idiopathic Parkinson's Disease. [PDF]

Mov Disord
Toh TS, Lit LC, Lim SY, Hor JW, Lew CY, Khairul Anuar AN, Tay YW, Black K, Lim JL, Zulkefli J, Lim KS, Ding HX, Padmanabhan S, Ahmad-Annuar A, Tan EK, Alessi DR, Sammler E, Tan AH.   +17 more
europepmc   +1 more source

Synergistic Effects of Multi-Kinase Inhibition on <i>LRRK2</i>-G2019S and Alpha-Synuclein Pathologies in Models of Parkinson's Disease. [PDF]

Biomedicines
Liu X, Baxley S, Hebron ML, Moussa C.
europepmc   +1 more source

Prediction of α-synuclein seed amplification assay positivity in remotely followed <i>LRRK2</i> G2019S carriers using a validated data-driven model. [PDF]

J Clin Transl Sci
Schneider RB, Auinger P, Venuto CS.
europepmc   +1 more source