Results 191 to 200 of about 19,899 (238)

LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal integrity via phosphorylation within its lipid-sensing ALPS2 motif. [PDF]

Front Mol Neurosci
Islam MS, Cóppola-Segovia V, Musso A, Moore DJ.   +3 more
europepmc   +1 more source

Biomarkers of Leucine-Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy. [PDF]

Mov Disord
Nielsen LK, Frost JLI, Vaughan DP, Real R, Fumi R, Jensen MT, Hodgson M, Stafford EJ, Wu L, Ansorge O, Quaegebeur A, Allinson KSJ, Warner TT, Jaunmuktane Z, Misbahuddin A, Leigh PN, Ghosh BCP, Bhatia KP, Church A, Kobylecki C, Hu MTM, Rowe JB, Shomo AA, Graham DL, Mabrouk OS, Morris HR, Sammler EM, Jabbari E.   +27 more
europepmc   +1 more source

Multilayered interplay between the cGAS-STING pathway and autophagy. [PDF]

Autophagy Rep
Huang Z, Gao X, Lin J, Feng D, Lu G.
europepmc   +1 more source

LRRK2 and GBA1 in Lewy body diseases: neuropathological subtypes at opposite ends of a spectrum? [PDF]

Mol Neurodegener
Jha V, Kalia LV.
europepmc   +1 more source

Timing of device-aided therapy initiation in Parkinson's disease: reference estimates for healthcare planning and biological heterogeneity. [PDF]

Clin Park Relat Disord
Ledingham D, Stewart CB, Sathyanarayana S, Foster V, Iredale R, Galley D, Baker MR, Pavese N.   +7 more
europepmc   +1 more source

The emerging role and therapeutic targeting of autophagy-lysosome pathway in the pathogenesis of Parkinson's disease. [PDF]

Transl Neurodegener
Shimizu T, Isik S, Kamath N, Yue Z.
europepmc   +1 more source

Editorial: Emerging mechanisms in neurodegenerative disease pathogenesis: vertebrate and invertebrate model organisms. [PDF]

Front Mol Neurosci
Almeida S, Song Y, Marques F, Sharma N.
europepmc   +1 more source

Cellular processes associated with LRRK2 function and dysfunction [PDF]

FEBS Journal, 2015
Mutations in the leucine-rich repeat kinase 2 (LRRK2) encoding gene are the most common cause of monogenic Parkinson's Disease (PD). The identification of LRRK2 polymorphisms associated with increased risk for sporadic PD, as well as the observation that
Claudia Manzoni, Rina Bandopadhyay
exaly   +1 more source

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LRRK2 and neurodegeneration

Acta Neuropathologica, 2009
Mutations in leucine-rich repeat kinase 2 gene (PARK8/LRRK2) encoding the protein Lrrk2 are causative of inherited and sporadic Parkinson's disease (PD) with phenotypic manifestations of frontotemporal lobar degeneration, corticobasal degeneration and associated motor neuron disease in some patients, and with variable penetrance.
Gabriel, Santpere, Isidre, Ferrer
openaire   +2 more sources

PARK8 LRRK2 parkinsonism

Current Neurology and Neuroscience Reports, 2006
Parkinson's disease (PD) is the most common form of parkinsonism, affecting nearly 2% of people older than 65 years of age. Symptomatic treatment has been available for decades, but to date there is no treatment retarding disease progression. Over the past decade several genes causing parkinsonism have been identified in families with a mendelian ...
Kristoffer, Haugarvoll, Zbigniew K, Wszolek   +1 more
openaire   +2 more sources