Results 141 to 150 of about 27,519 (289)
LSD1+8a is an RNA biomarker of neuroendocrine prostate cancer
Neoplasia: An International Journal for Oncology ResearchBackground: Lysine-specific demethylase 1 (LSD1) is a histone demethylase and regulator of differentiation, including in cancer. A neuronal-specific isoform of LSD1—LSD1+8a—has been shown to play a key role in promoting neuronal differentiation in the ...
Anbarasu Kumaraswamy +14 more
doaj +1 more source
LSD1 inhibitors disrupt the GFI1 transcription repressor complex
Molecular & Cellular Oncology, 2018 Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1 ...
Alba Maiques-Diaz +3 more
doaj +1 more source
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program
Cell Reports, 2016 Zfp516, a brown fat (BAT)-enriched and cold-inducible transcription factor, promotes transcription of UCP1 and other BAT-enriched genes for non-shivering thermogenesis. Here, we identify lysine-specific demethylase 1 (LSD1) as a direct binding partner of
Audrey Sambeat +6 more
doaj +1 more source
Histone H3 peptide based LSD1-selective inhibitors
Bioorganic & Medicinal Chemistry Letters, 2015 A series of candidates for the histone H3 peptide based LSD1-selective inhibitor were designed and synthesized. Among peptides 1a-c and 2a-c, peptide 1a, which has a phenylcyclopropylamine (PCPA) moiety at Lys-4 of the 21 amino acid residues of histone H3, was the most potent LSD1-selective inhibitor.
Taeko, Kakizawa +4 more
openaire +3 more sources
Cellular analysis of the action of epigenetics drugs and probes [PDF]
, 2017 Small molecule drugs and probes are important tools in drug discovery, pharmacology, and cell biology. This is of course also true for epigenetic inhibitors.
A. Ganesan +12 more
core +1 more source
Haematologica, 2019 Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD1 ...
Kimberly N. Smitheman +19 more
doaj +1 more source
Regulation of alphaherpesvirus infections by the ICP0 family of proteins [PDF]
, 2013 Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) is important for the regulation of lytic and latent viral infection. Like the related proteins expressed by other alphaherpesviruses, ICP0 has a zinc-stabilized RING finger domain that ...
Boutell, Chris, Everett, Roger
core +1 more source
Cell Reports, 2014 Summary: Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear.
Changmeng Cai +15 more
doaj +1 more source
Phosphoproteomic analysis on ovarian follicles reveals the involvement of LSD1 phosphorylation in Chicken follicle selection [PDF]
, 2023 Yanhong Zhang +5 more
openalex +1 more source