Results 131 to 140 of about 22,216 (225)
Cooperative role of LSD1 and CHD7 in regulating differentiation of mouse embryonic stem cells
Scientific ReportsLysine-specific histone demethylase 1 (LSD1) is a histone demethylase that plays a critical role in epigenetic regulation by removing the methyl group from mono- and di-methylated lysine 4 on histone H3 (H3K4me1/2), acting as a repressor of gene ...
Sandhya Malla +9 more
doaj +1 more source
TERRA-LSD1 phase separation promotes R-loop formation for telomere maintenance in ALT cancer cells
Nature CommunicationsThe telomere repeat-containing RNA (TERRA) forms R-loops to promote homology-directed DNA synthesis in the alternative lengthening of telomere (ALT) pathway.
Meng Xu +15 more
doaj +1 more source
The precise spatiotemporal regulation of gene expression is essential for all aspects of cellular function. Dysregulation of gene transcription can lead to serious pathologies, including severe malignancies and ultimately cell death. Consequently, complex regulatory mechanisms are essential to maintain and adapt gene expression in response to internal ...
openaire +2 more sources
Correction to “Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1” [PDF]
Journal of Medicinal Chemistry, 2021 Xing-Jie Dai +6 more
openaire +1 more source
GSK-LSD1, an LSD1 inhibitor, quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro
Signal Transduction and Targeted Therapy, 2020 Hong, Kyung Soo +6 more
openaire +3 more sources
Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression. [PDF]
J Clin InvestKuprasertkul N +20 more
europepmc +1 more source
A synergistic interaction between PRMT5 and LSD1 inhibitors in AML. [PDF]
Sci AdvParam NJ +28 more
europepmc +1 more source