Results 131 to 140 of about 12,312 (182)

The Histone-Lysine N-Methyltransferase (KMT2) Family in Health and Disease. [PDF]

MedComm (2020)
Wang Q, Bo Z, Zhang Y, Chen Y, Wang Z, Tong S, Xu A, Zhang J, Liu Y.   +8 more
europepmc   +1 more source

Androgen receptor reactivation in castration-resistant prostate cancer: mechanisms, epigenetic adaptation, and therapeutic vulnerabilities. [PDF]

Front Oncol
Guo J, Wu K, Ma Z, Guo S, Wang F, Lu L.
europepmc   +1 more source

FLI1 Expression in Invasive Breast Carcinoma: Clinicopathological Correlations and Prognostic Implications. [PDF]

Genes (Basel)
Doly NJ, Lee DY, Tahsin KN, Akhter J, Sultana S, Khatun J, Chua SZ, Banu AT, Chen Q, Iqbal J.   +9 more
europepmc   +1 more source

<i>N</i>'‑(1-Phenylethylidene)benzohydrazide Cytotoxicity Is Lysine-Specific Demethylase 1 Independent and Linked to Iron-Sulfur Cluster Disruption in Ewing Sarcoma. [PDF]

ACS Pharmacol Transl Sci
Sherman JW, Rask GC, Xiong B, Tokarsky EJ, Dreher RD, Weinglass A, Hayes C, Duncan A, Weerapana E, Theisen ER.   +9 more
europepmc   +1 more source

Identification and expression profiling of LSD genes reveal their role in developmental and abiotic stress conditions in maize. [PDF]

Front Plant Sci
Zhao D, Wei L, Guo J, Guo Z, Guo L, Gao J, Cui H, Tai R, Guan P, Zhang L, Liu P, Jin Y.   +11 more
europepmc   +1 more source

Experimental Validation of Genome-Environment Associations in Arabidopsis. [PDF]

Mol Ecol
Luo Y, Lorts CM, Lawrence-Paul EH, Lasky JR.   +3 more
europepmc   +1 more source

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A comprehensive comparative study on LSD1 in different cancers and tumor specific LSD1 inhibitors

European Journal of Medicinal Chemistry, 2022
LSD1 was significantly over-expressed in several cancer types, and its aberrant overexpression was revealed to play a crucial role in the initiation and progression of cancer. Several LSD1 inhibitors that were discovered and developed so far were found to be effective in attenuating tumor growth in both in vivo and in vitro studies.
Hong-Min Liu, Jianshu Dong, Waqar Pervaiz   +2 more
exaly   +3 more sources

Baicalin, a natural LSD1 inhibitor

Bioorganic Chemistry, 2016
Baicalin is one of the active ingredients in the skullcap, with a variety of pharmacological effects, such as blood pressure reduction, sedation, liver-protection, gallbladder-protection, anti-bacteria, and anti-inflammation. In our study, baicalin was first characterized as a LSD1 inhibitor with an IC50 of 3.01μM and showed strong LSD1 inhibitory ...
Hong-Min Liu, Yi-Chao Zheng, Bin Yu
exaly   +3 more sources

Modeling LSD1-Mediated Tumor Stagnation

Bulletin of Mathematical Biology, 2021
LSD1 (KDMA1) has gained attention in the last decade as a cancer biomarker and drug target. In particular, recent work suggests that LSD1 inhibition alone reduces tumor growth, increases T cell tumor infiltration, and complements PD1/PDL1 checkpoint inhibitor therapy.
Jesse Milzman, Wanqiang Sheng, Doron Levy   +2 more
openaire   +3 more sources

LSD1 Makes Fat Colorful

Trends in Endocrinology & Metabolism, 2017
The histone lysine-specific demethylase 1 (LSD1) is a new and important player in the regulation of brown fat identity and function. In a recent Cell Reports article, Duteil et al. show that LSD1 exerts its effects via regulation of specific histone marks as well as through association with co-repressor complexes.
Straub LG, Wolfrum C
openaire   +3 more sources