Results 111 to 120 of about 22,216 (225)

A Cluster of Three snoRNAs Including Jouvence Required in the Gut Determines Lifespan and Confers Neuroprotection Through Metabolic Parameters

Aging Cell, Volume 25, Issue 4, April 2026.
The disruption of a cluster of three snoRNAs in the epithelium of the gut deregulates the lipid and sterol (including the cholesterol) homeostasis. At the whole‐organism level, this chronic deregulation, all along life, decreases lifespan and leads to neurodegenerative lesions in old flies.
Sara Al Issa, Théo Gauvrit, Patricia Daira, Nathalie Bernoud‐Hubac, Jean‐René Martin   +4 more
wiley   +1 more source

Computational modeling to elucidate molecular mechanisms of epigenetic memory

, 2015
How do mammalian cells that share the same genome exist in notably distinct phenotypes, exhibiting differences in morphology, gene expression patterns, and epigenetic chromatin statuses?
Alsing, Andrews, Ang, Angel, Arnold, Bannister, Barth, Beisel, Benecke, Bhattacharya, Binder, Black, Buscaino, Bushey, Canzio, Cowieson, David-Rus, Dayarian, Deal, Dodd, Fonseca, Freddolino, Gaffney, Grauffel, Greer, Grewal, Grigoryev, Hanna, Hathaway, Henikoff, Herranz, Hodges, Jacobs, Korolev, Korolev, Kouzarides, Ku, Kulaeva, Lin, Margreitter, Margueron, Mendenhall, Muller, Papp, Pasque, Peinado, Piana, Potoyan, Prohaska, Raghavan, Rohlf, Sanbonmatsu, Sanli, Schwab, Schwammle, Sedighi, So, Sontag, Steffen, Takahashi, Teif, Thon, Wocjan, Xu, Yang, Yuan, Zee, Zhang, Zhang   +68 more
core   +1 more source

Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia. [PDF]

, 2015
Acute myeloid leukemia (AML), the most prevalent acute leukemia in adults, is an aggressive hematological malignancy arising in hematopoietic stem and progenitor cells.
Gallipoli, Paolo, Giotopoulos, George, Huntly, Brian JP   +2 more
core   +2 more sources

Current perspectives on KMT2A fusion proteins and menin inhibition in paediatric acute myeloid leukaemia

The FEBS Journal, Volume 293, Issue 8, Page 2159-2177, April 2026.
Genetic rearrangements resulting in the expression of KMT2A fusion alleles can lead to dramatic transcriptional disturbances that contribute to the onset of acute leukaemias. Fortunately, menin inhibition has emerged as a promising new class of targeted therapy.
Lydia Elaine Roets, Graeme Greenfield, Katrina Mairead Lappin   +2 more
wiley   +1 more source

LSD1 modulates the bone metastasis of breast cancer cells through hnRNPA2B1-mediated sorting of exosomal miRNAs

Cell Death Discovery
Bone metastasis is a key contributor to morbidity and mortality of breast cancer patients. We have previously shown that exosomal miRNAs derived from LSD1 knockdown (KD) breast cancer cells inhibit osteoblast differentiation and promote osteoclast ...
Ziyu Liu, Benkai Xin, Nan Zhang, Peipei An, Yueru Shi, Jingtong Yang, Youzhong Wan, Yuquan He, Xin Hu   +8 more
doaj   +1 more source

LSD1+8a is an RNA biomarker of neuroendocrine prostate cancer

Neoplasia: An International Journal for Oncology Research
Background: Lysine-specific demethylase 1 (LSD1) is a histone demethylase and regulator of differentiation, including in cancer. A neuronal-specific isoform of LSD1—LSD1+8a—has been shown to play a key role in promoting neuronal differentiation in the ...
Anbarasu Kumaraswamy, Rahul Mannan, Olivia A. Swaim, Eva Rodansky, Xiao-Ming Wang, Aaron Udager, Rohit Mehra, Hui Li, Colm Morrissey, Eva Corey, Michael C. Haffner, Peter S. Nelson, Arul M. Chinnaiyan, Joel A. Yates, Joshi J. Alumkal   +14 more
doaj   +1 more source

Histone H3 peptide based LSD1-selective inhibitors

Bioorganic & Medicinal Chemistry Letters, 2015
A series of candidates for the histone H3 peptide based LSD1-selective inhibitor were designed and synthesized. Among peptides 1a-c and 2a-c, peptide 1a, which has a phenylcyclopropylamine (PCPA) moiety at Lys-4 of the 21 amino acid residues of histone H3, was the most potent LSD1-selective inhibitor.
Taeko, Kakizawa, Yosuke, Ota, Yukihiro, Itoh, Hiroki, Tsumoto, Takayoshi, Suzuki   +4 more
openaire   +3 more sources

Helicobacter pylori regulates iNOS promoter by histone modifications in human gastric epithelial cells. [R. Pero* corresponding author] [PDF]

, 2012
Inducible nitric oxide synthase (iNOS) expression is altered in gastrointestinal diseases. Helicobacter pylori (Hp) infection may have a critical role in iNOS disregulation.
AT Franco, BM Turner, C Chan, C Magerl, CC Wang, D Fukumura, DM Schmidt, E Metzger, F Fuks, F Perri, Francesca Lembo, G Le’Negrate, H Kolb, H Suzuki, J Parsonnet, JC Atherton, JM Kim, JW Lim, K Komoto, K Uno, KJ Livak, LJ Doorn van, Lorenzo Chiariotti, M Erkisi, M Gerhard, M Romano, M Yang, MA Hamon, MF Maat de, MG Lee, MG Lee, P Lejeune, PT Georgel, Q Zheng, R Pero, RA Aras, Raffaela Pero, RH Liu, RM Peek, S Fu, SF Kim, Silvia Peluso, Simona Keller, SK Pathak, SL Berger, T Angrisano, T Jenuwein, T Kouzarides, T Maekita, T Motoyama, T Watanabe, Tiziana Angrisano, TL Cover, WC You, WG Deng, Y Naito, Y Naito, Y Saito, YJ Chang, YJ Shi   +59 more
core   +1 more source

Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer

Frontiers in Immunology, 2019
Macrophages play an important role in regulating the tumor microenvironment (TME). Here we show that classical (M1) macrophage polarization reduced expression of LSD1, nuclear REST corepressor 1 (CoREST), and the zinc finger protein SNAIL.
Abel H. Y. Tan, WenJuan Tu, Robert McCuaig, Kristine Hardy, Thomasina Donovan, Sofiya Tsimbalyuk, Jade K. Forwood, Sudha Rao   +7 more
doaj   +1 more source

Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy. [PDF]

, 2017
Androgen receptor (AR) signaling remains the major oncogenic pathway in prostate cancer (PCa). Androgen-deprivation therapy (ADT) is the principle treatment for locally advanced and metastatic disease.
Cucchiara, Vito, Evans, Christopher P, Gao, Allen C, Mirone, Vincenzo, Rosenfeld, Michael G, Yang, Joy C   +5 more
core   +2 more sources