Osteoarthritis: Epidemiology, Pathogenesis, and Treatment
MedComm, Volume 7, Issue 4, April 2026.Osteoarthritis is a prevalent degenerative joint disease with a growing global burden. Its development involves complex interactions among epidemiological factors, pathological changes, molecular signaling, and epigenetic regulation. Understanding these mechanisms provides insights into disease progression and supports the development of therapeutic ...
Tianrui Chen +8 more
wiley +1 more source
Relationship between seed harvesting method and seed physiological quality for a number of Pioneer maize hybrids [PDF]
, 2012 The seed germination and seed vigor of eight Pioneer Hi-Bred maize hybrids were evaluated immediately after harvesting and a year later. The aim was to determine whether the seed showed loss of germination and vigor when shelled mechanically.
Anda, Angéla +3 more
core +1 more source
The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region [PDF]
, 2019 BACKGROUND: The cell-cycle inhibitor p57kip2 plays a critical role in mammalian development by coordinating cell proliferation and differentiation in many cell types.
Andresini, Oriella +5 more
core +4 more sources
TBL1 is required for the mesenchymal phenotype of transformed breast cancer cells [PDF]
, 2019 The epithelial-to-mesenchymal transition (EMT) and its reversion (MET) are related to tumor cell dissemination and migration, tumor circulating cell generation, cancer stem cells, chemoresistance, and metastasis formation.
García Martínez, Jorge +4 more
core +2 more sources
LSD1 deficiency in breast cancer cells promotes the formation of pre-metastatic niches
npj Precision OncologyLysine-specific demethylase 1 (LSD1), a histone demethylating enzyme, plays a crucial role in cancer metastasis. Studies show LSD1 knockout promotes breast cancer lung metastasis, but it’s unknown if it alters the lung microenvironment for metastasis. In
Yutong Yao +11 more
doaj +1 more source
Journal of Clinical and Translational ScienceOBJECTIVES/GOALS: LSD1 is a histone demethylase important in GBM regulation. Our goal is to design a therapeutic strategy for LSD1 inhibitors to meet clinical needs in GBM. Despite the abundance of LSD1 inhibitors, resistance emerges in GBM mouse models.
Lea Stitzlein +8 more
doaj +1 more source
Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases
MedComm, Volume 7, Issue 4, April 2026.Posttranslational modifications (PTMs) serve as rapid and reversible molecular switches that reshape protein activity, stability, and interactomes, thereby governing virtually all physiological cues ranging from signal transduction to epigenetic memory. Mass spectrometry‐based proteomics has substantially expanded our understanding of PTM emergence and
Shuning Zhang +3 more
wiley +1 more source
Pharmacological Inhibition of LSD1 for Cancer Treatment
Molecules, 2018 Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed in many cancers, where it impedes differentiation and contributes to cancer cell proliferation, cell metastasis and invasiveness, and is associated with inferior prognosis ...
Guan-Jun Yang +4 more
openaire +3 more sources
Characterization of the Epigenetic Changes During Human Gonadal Primordial Germ Cells Reprogramming [PDF]
, 2016 Epigenetic reprogramming is a central process during mammalian germline development. Genome-wide DNA demethylation in primordial germ cells (PGCs) is a prerequisite for the erasure of epigenetic memory, preventing the transmission of epimutations to the ...
Eguizábal, Cristina +5 more
core +1 more source
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program
Cell Reports, 2016 Zfp516, a brown fat (BAT)-enriched and cold-inducible transcription factor, promotes transcription of UCP1 and other BAT-enriched genes for non-shivering thermogenesis. Here, we identify lysine-specific demethylase 1 (LSD1) as a direct binding partner of
Audrey Sambeat +6 more
doaj +1 more source