Results 91 to 100 of about 22,216 (225)
The faah gene is the first direct target of estrogen in the testis: role of histone demethylase LSD1 [PDF]
, 2012 Estrogen (E(2)) regulates spermatogenesis, yet its direct target genes have not been identified in the testis. Here, we cloned the proximal 5' flanking region of the mouse fatty acid amide hydrolase (faah) gene upstream of the luciferase reporter gene ...
Di Giacomo, D +6 more
core +1 more source
iScienceSummary: Epigenetic regulation of heart development remains incompletely understood. Here we show that LSD1, a histone demethylase, plays a crucial role in regulating cardiomyocyte proliferation during heart development.
Huahua Liu +14 more
doaj +1 more source
LSD1 inhibitors disrupt the GFI1 transcription repressor complex
Molecular & Cellular Oncology, 2018 Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1 ...
Alba Maiques-Diaz +3 more
doaj +1 more source
Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation. [PDF]
PLoS Pathogens, 2017 The histone demethylase LSD1 has been known as a key transcriptional coactivator for DNA viruses such as herpes virus. Inhibition of LSD1 was found to block viral genome transcription and lytic replication of DNA viruses.
Jiaoyu Shan +18 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue 4, Page 877-893, April 2026.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines [PDF]
, 2013 BACKGROUND: Lysine-specific demethylase 1 (LSD1, also known as KDM1A and AOF2) is a chromatin-modifying activity that catalyzes the removal of methyl groups from lysine residues in histone and non-histone proteins, regulating gene transcription.
Ivan Garcia-Bassets, Sergiy Konovalov
core +2 more sources
Lsd1 restricts the number of germline stem cells by regulating multiple targets in escort cells. [PDF]
PLoS Genetics, 2014 Specialized microenvironments called niches regulate tissue homeostasis by controlling the balance between stem cell self-renewal and the differentiation of stem cell daughters.
Susan Eliazer +5 more
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.This registry‐based analysis of 1183 MS clinical trials (2004–2024) shows sustained global activity and a marked increase in mainland China after 2018, predominantly driven by late‐phase and bioequivalence studies. Trial density varied across regions, and IFNAR, CD20, and S1PR1 were the most frequently investigated targets. ABSTRACT Background Multiple
Chaoyang Chen +7 more
wiley +1 more source
Discovery of an LSD1 PROTAC degrader
Proceedings of the National Academy of SciencesAberrant expression of lysine-specific demethylase 1 (LSD1) has been implicated in various cancers, including acute myeloid leukemia (AML). Recent studies have revealed both catalytic and noncatalytic oncogenic functions of LSD1, which cannot be effectively addressed by traditional small-molecule inhibitors.
Amir Hosseini +9 more
openaire +2 more sources
Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions [PDF]
, 2014 Mammalian gene regulation is dependent on tissue-specific enhancers that can act across large distances to influence transcriptional activity1-3. Mapping experiments have identified hundreds of thousands of putative enhancers whose functionality is ...
Bernstein, Bradley E. +6 more
core +1 more source