Results 91 to 100 of about 12,312 (182)

PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory

Scientific Reports, 2017
Lysine-specific demethylase 1 (LSD1) is a histone demethylase that participates in transcriptional repression or activation. Recent studies reported that LSD1 is involved in learning and memory.
Chae-Seok Lim, Hye Jin Nam, Jaehyun Lee, Dongha Kim, Ja Eun Choi, SukJae Joshua Kang, Somi Kim, Hyopil Kim, Chuljung Kwak, Kyu-Won Shim, Siyong Kim, Hyoung-Gon Ko, Ro Un Lee, Eun-Hae Jang, Juyoun Yoo, Jaehoon Shim, Md Ariful Islam, Yong-Seok Lee, Jae-Hyung Lee, Sung Hee Baek, Bong-Kiun Kaang   +20 more
doaj   +1 more source

Cooperative role of LSD1 and CHD7 in regulating differentiation of mouse embryonic stem cells

Scientific Reports
Lysine-specific histone demethylase 1 (LSD1) is a histone demethylase that plays a critical role in epigenetic regulation by removing the methyl group from mono- and di-methylated lysine 4 on histone H3 (H3K4me1/2), acting as a repressor of gene ...
Sandhya Malla, Carlos Martinez-Gamero, Kanchan Kumari, Cyrinne Achour, Georgios Mermelekas, David Martinez-Delgado, Alba Coego, Diana Guallar, Angel-Carlos Roman, Francesca Aguilo   +9 more
doaj   +1 more source

TERRA-LSD1 phase separation promotes R-loop formation for telomere maintenance in ALT cancer cells

Nature Communications
The telomere repeat-containing RNA (TERRA) forms R-loops to promote homology-directed DNA synthesis in the alternative lengthening of telomere (ALT) pathway.
Meng Xu, Dulmi Senanayaka, Rongwei Zhao, Tafadzwa Chigumira, Astha Tripathi, Jason Tones, Rachel M. Lackner, Anne R. Wondisford, Laurel N. Moneysmith, Alexander Hirschi, Sara Craig, Sahar Alishiri, Roderick J. O’Sullivan, David M. Chenoweth, Nicholas J. Reiter, Huaiying Zhang   +15 more
doaj   +1 more source

Mechanisms of LSD1 regulation

The precise spatiotemporal regulation of gene expression is essential for all aspects of cellular function. Dysregulation of gene transcription can lead to serious pathologies, including severe malignancies and ultimately cell death. Consequently, complex regulatory mechanisms are essential to maintain and adapt gene expression in response to internal ...
openaire   +2 more sources

Inhibition of histone demethylase LSD1 suppresses CD47 expression and enhances efficacy of CD47 blockade in breast cancer. [PDF]

J Immunother Cancer
Jiang F, Shen Y, Li B, Henry M, Davidson N, Huang Y.   +5 more
europepmc   +1 more source

KIT-dependent acute myeloid leukemias are responsive to LSD1 inhibition. [PDF]

Clin Epigenetics
Abdel-Aziz AK, Saadeldin MK.
europepmc   +1 more source

Dual Targeting of EZH2 and LSD1 Suppresses Hepatocellular Carcinoma via Disruption of Sonic Hedgehog Signaling. [PDF]

Int J Mol Sci
Yun H, Guruvaiya P, Levurdiak O, Basnakian AG, Boerma M, Safe S, Kim K.   +6 more
europepmc   +1 more source

LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC. [PDF]

Nat Commun
Machida T, Gong Y, Tsukioka S, Onodera A, Nakayama A, Hashimoto N, Fuchigami T, Nishimura M, Ogino T, Kurimoto R, Uematsu Y, Suzuki H, Yu H, Chen M, Yokoyama M, Sakuma I, Taki Y, Kono T, Miki T, Motohashi S, Kawashima Y, Ohara O, Yamashita S, Suzuki T, Hatanaka R, Kodama Y, Ohkubo S, Tanaka T.   +27 more
europepmc   +1 more source

LSD1 inhibition ameliorates congenital dyserythropoietic anemia type II. [PDF]

Sci Transl Med
Yu L, Wang Y, King R, Myers G, Deng K, McGee B, Friedman A, Balbin-Cuesta G, Lin Z, Drysdale C, Liu X, Min JC, Kerpet C, Guan Y, Gallagher PJ, Ozel AB, Robida A, Engel JD, Khoriaty R.   +18 more
europepmc   +1 more source

Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression. [PDF]

J Clin Invest
Kuprasertkul N, Moore AF, D'souza CA, Chini J, Ko EK, Huang S, Zhang S, Anderson AS, Egolf S, Pinheiro LV, Jaccard A, Magahis CT, Bao L, Aubert Y, Olingou C, Prouty SM, Brennan-Crispi D, Hill DA, Seykora JT, Wellen KE, Capell BC.   +20 more
europepmc   +1 more source