Results 81 to 90 of about 12,312 (182)
Cell Reports, 2014 Summary: Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear.
Changmeng Cai +15 more
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SYNTHESIS, LSD1 INHIBITORY ACTIVITY, AND LSD1 BINDING MODEL OF OPTICALLY PURE LYSINE-PCPA CONJUGATES
Computational and Structural Biotechnology Journal, 2014 Compounds that inhibit the catalytic function of lysine-specific demethylase 1 (LSD1) are interesting as therapeutic agents. Recently, we identified three lysine-phenylcyclopropylamine conjugates, NCD18, NCD25, and NCD41, which are potent LSD1 inactivators.
Yukihiro Itoh +4 more
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LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program
Cell Reports, 2016 Zfp516, a brown fat (BAT)-enriched and cold-inducible transcription factor, promotes transcription of UCP1 and other BAT-enriched genes for non-shivering thermogenesis. Here, we identify lysine-specific demethylase 1 (LSD1) as a direct binding partner of
Audrey Sambeat +6 more
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Cell Death DiscoveryBone metastasis is a key contributor to morbidity and mortality of breast cancer patients. We have previously shown that exosomal miRNAs derived from LSD1 knockdown (KD) breast cancer cells inhibit osteoblast differentiation and promote osteoclast ...
Ziyu Liu +8 more
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LSD1+8a is an RNA biomarker of neuroendocrine prostate cancer
Neoplasia: An International Journal for Oncology ResearchBackground: Lysine-specific demethylase 1 (LSD1) is a histone demethylase and regulator of differentiation, including in cancer. A neuronal-specific isoform of LSD1—LSD1+8a—has been shown to play a key role in promoting neuronal differentiation in the ...
Anbarasu Kumaraswamy +14 more
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Pharmacological Inhibition of LSD1 for Cancer Treatment
Molecules, 2018 Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed in many cancers, where it impedes differentiation and contributes to cancer cell proliferation, cell metastasis and invasiveness, and is associated with inferior prognosis ...
Guan-Jun Yang +4 more
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Clinical and Translational MedicineBackground Immune checkpoint blockade, particularly targeting programmed death 1 (PD‐1) and programmed death ligand 1 (PD‐L1), shows promise in treating hepatocellular carcinoma (HCC).
Chen Liang +23 more
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Research progress of LSD1 in regulating tumor immune mechanisms [PDF]
Jichu yixue yu linchuangLysine-specific demethylase 1(LSD1) plays a regulatory role in tumor immunity. LSD1 affects CD8+T cell infiltration by regulating AGO2 protein level, and it is required for normal B cell proliferation and differentiation via reducing local chromatin ...
LONG Lijuan, SONG Songze, YE Qinong, LIN Jing
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The scaffolding function of LSD1 controls DNA methylation in mouse ESCs
Nature CommunicationsLysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development.
Sandhya Malla +24 more
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Methionine concentration regulates LSD1 acetylation in glioma cells
Amino AcidsGlioma is a highly aggressive brain cancer with poor prognosis, characterized by vigorous methionine metabolism. While methionine restriction demonstrates broad anticancer effects, its mechanistic relationship with epigenetic regulators in glioma remains
Jie Chang +4 more
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