Results 81 to 90 of about 22,216 (225)

The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain [PDF]

, 2020
Chromatin remodelling and transcription factors play important roles in lineage commitment and development through control of gene expression. Activation of selected lineage-specific genes and repression of alternative lineage-affiliated genes results in
Biasutto, Antonio J, Gilbert, Robert C G, Karia, Dimple, Mancini, Erika J, Porcher, Catherine   +4 more
core   +1 more source

The deubiquitinase USP38 affects cellular functions through interacting with LSD1

Biological Research, 2018
Background Deubiquitination is a posttranslational protein modification prevalent in mammalian cells. Deubiquitinases regulate the functions of the target protein by removing its ubiquitin chain.
Wenbin Liu, Qi Zhang, Yuanyuan Fang, Yanan Wang   +3 more
doaj   +1 more source

Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors

Acta Pharmaceutica Sinica B, 2020
Histone lysine specific demethylase 1 (LSD1) has become a potential therapeutic target for the treatment of cancer. Discovery and develop novel and potent LSD1 inhibitors is a challenge, although several of them have already entered into clinical trials.
Liying Ma, Haojie Wang, Yinghua You, Chaoya Ma, Yuejiao Liu, Feifei Yang, Yichao Zheng, Hongmin Liu   +7 more
doaj   +1 more source

Discovery of novel sulphonamide hybrids that inhibit LSD1 against bladder cancer cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Aim:A series of sulphonamide hybrids were designed, synthesised, and identified as potential lysine-specific demethylase 1 (LSD1) inhibitors.Materials and methods: Bladder cancer cell lines were cultured to evaluate the antiproliferative activity ...
Jia Liu, Xingwang Zhu, Liu Yu, Minghuan Mao   +3 more
doaj   +1 more source

VqLecRKV.4 and VqBAK1 Modulate Grapevine Resistance to Powdery Mildew by Regulating Dynamic Balance of ROS

Plant Biotechnology Journal, EarlyView.
ABSTRACT Grapevine powdery mildew, caused by the fungal pathogen Erysiphe necator, severely impacts plant growth and berry quality. However, the grapevine receptors and molecular mechanisms underlying grapevine resistance to E. necator remain poorly understood.
Yajuan Li, Ruilin Li, Zhuoyu Liu, Kewei You, Rongxin Li, Chen Jiao, Zhenjiang Wei, Zhi Li, Yijie Zhao, Xiping Wang   +9 more
wiley   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Human Histone Demethylase LSD1 Reads the Histone Code [PDF]

Journal of Biological Chemistry, 2005
Human histone demethylase LSD1 is a flavin-dependent amine oxidase that catalyzes the specific removal of methyl groups from mono- and dimethylated Lys4 of histone H3. The N-terminal tail of H3 is subject to various covalent modifications, and a fundamental question in LSD1 biology is how these epigenetic marks affect the demethylase activity.
F. Forneris, C. Binda, M.A. Vanoni, E. Battaglioli, A. Mattevi   +4 more
openaire   +4 more sources

Genes involved in barley yellow dwarf virus resistance of maize [PDF]

, 2014
KEY MESSAGE: The results of our study suggest that genes involved in general resistance mechanisms of plants contribute to variation of BYDV resistance in maize. ABSTRACT: With increasing winter temperatures in Europe, Barley yellow dwarf virus (BYDV) is
Habekuss, A., Horn, F., Stich, B.
core   +2 more sources

The Role of Histone Modifications in Plant Priming and Their Analysis by Chromatin Immunoprecipitation

Physiologia Plantarum, Volume 178, Issue 3, May/June 2026.
ABSTRACT Plants are frequently exposed to adverse conditions. Priming, also known as acclimation or hardening, induces stress memory and prepares plants for future challenges by activating defense and protective mechanisms. For this reason, priming is an effective means to maintain plant yield in the face of climate change. Memory behind the priming is
Aslihan Temel, Nihal Gören‐Sağlam
wiley   +1 more source

Targeting LSD1 and FOXA1 in prostate cancer

Nature Genetics, 2020
FOXA1 is a key pioneer factor in androgen-receptor activity but has been an elusive drug target. A new study shows that inhibition of the associated cofactor LSD1 modifies the methylation state of FOXA1, thus resulting in chromatin dissociation and tumor inhibition, even in models of treatment-resistant prostate cancer.
Omarjee, Soleilmane, Carroll, Jason S
openaire   +2 more sources